Table 1.

IRF7-related autoimmune diseases.

Diseases	Mechanisms and Functions	References
Multiple sclerosis/EAE	IRF7 inhibits the infiltration of macrophages and T cells, decreases the expression of CCL2, CXCL10, IL-1ß, IL17.	(141, 142)
Rheumatoid arthritis	IRF7 inhibits proinflammatory cytokine, promotes anti-inflamamtory cytokine IL-1ß.	(143)
Systemic lupus erythematosus (SLE)	IRF7 is a susceptibility locus, TRAP and Gfil prevent susceptibility to SLE by regulating nuclear transport of IRF7.	(106, 110, 144–154)
Systemic sclerosis( SSc)	The overexpression of IRF7 forms complexes with smad3, mediates the fibrosis.	(43, 155–158)
Autoimmune pancreatitis(AIP)	The IRF7-IFN-I-IL-33 axis mediates the development of AIP.	(159–162)
Autoimmune thyroid diseases (AITD)	IRF7 SNP is associated with increased susceptibility to AITD.	(163–165)
Diabetes	IRF7 interacts with Foxp3/CD8+T, affects the induction of TID, the STAT1-IRF7-MHC I complex axis accelerates the process of TID through IRF7-STAT2 cascade signals and promotes the proliferation of CD8+ T cells. IRF7 interacts with MCP-1 promotes the T2D development.	(166–172)