Table 2.
Cytokine levels in serum and CSF from FES patients and controls
| Cytokine | Cont [mean (Q1;Q2;n)] | FES [ean (Q1;Q2;n)] | U test | Cliff’s delta |
|---|---|---|---|---|
| Serum | ||||
| IFN-α2 | 9.213 (5.928;23.863;20) | 11.46 (5.52;29.21;20) | 0.698 | − 0.075 |
| IFN-γ | 9.981 (7.183;30.639;13) | 15.37 (5.56;40.08;14) | 0.616 | − 0.121 |
| IL-10 | 13.36 (7.19;33.38;20) | 21.32 (13.02;39.67;20) | 0.218 | − 0.230 |
| IL-12p70 | 13.02 (9.95;39.49;17) | 14.36 (8.32;23.80;17) | 0.730 | 0.073 |
| IL-17A | 4.854 (2.895;13.419;19) | 3.731 (2.997;6.110;19) | 0.201 | 0.247 |
| IL-18 | 345.3 (242.1;417.3;21) | 358.6 (240.0;565.3;20) | 0.561 | − 0.110 |
| IL-23 | 47.84 (25.85;100.07;18 | 49.18 (35.71;79.19;17) | 0.883 | − 0.033 |
| IL-33 | 369.7 (115.0;555.0;19) | 306.9 (135.8;409.6;20) | 0.380 | 0.168 |
| IL-6 | 23.27 (14.27;70.30;20) | 25.32 (14.13;63.47;17) | 0.964 | 0.012 |
| IL-8 | 130.5 (62.3;221.1;19) | 76.46 (60.63;150.68;20) | 0.396 | 0.163 |
| MCP-1 | 220.0 (108.5;265.9;19) | 327.2 (225.7;463.8;20) | 0.007# | − 0.495 |
| TNF-α | 32.01 (15.29;228.23;16) | 27.16 (18.34;62.01;15) | 0.495 | 0.150 |
| CSF | ||||
| IL-8 | 118.0 (65.0;144.6;20) | 93.77 (67.78;107.23;20) | 0.429 | 0.150 |
| MCP-1 | 457.5 (401.8;595.7;21) | 452.1 (393.8;568.9;20) | 0.847 | 0.038 |
| CSF/serum | ||||
| IL-8 | 1.031 (0.485;1.567;18) | 1.117 (0.494;1.810;20) | 0.393 | 0.167 |
| MCP-1 | 1.934 (1.401;4.065;20) | 1.285 (0.931;2.393;20) | 0.030+ | 0.400 |
Mean (Q1;Q3) values are in pg/mL
Significant differences between FES and controls (Cont) are indicated in bold
#ART with covariate smoking: p = 0.024
+ART with covariate smoking: p = 0.114