Table 2.
Pyroptosis and immune cell analysis by single cell and bulk seq.
| PRGs | Single cell | Bulk seq | |||||||
|---|---|---|---|---|---|---|---|---|---|
| WGCNA | Immune infiltration | Prognosis | |||||||
| Cell type | log2FC | P value | Module | Cell type | Cell type | P value | HR | P value | |
| GZMA | CD8+ T cell | 1.34 | <0.0001 | Blue |
CD8+ T cell: 0.44 (2e–13) NK cell resting: -0.38 (5e–18) NK cell activated: 0.29 (7e–11) M1 Macrophage: 0.39 (1e–18) |
CD8+ T cell | 8.84e-203 | 0.526 (0.4–0.692) | <0.0001 |
| NK cell | 0.91 | <0.0001 | |||||||
| GSDMB | NK cell | 2.24 | <0.0001 | NK cell | 2.69e-20 | 0.749 (0.572–0.98) | 0.035 | ||
| NLRP1 | / | / | / | CD8+ T cell | 2.64e-36 | 0.605 (0.462–0.793) | <0.0001 | ||
| IL18 | / | / | / | Macrophage | 1.05e-103 | 0.517 (0.392–0.68) | <0.0001 | ||
| CHMP4A | T cell | 0.58 | <0.0001 | Neutrophil | 8.52e-09 | 0.595 (0.454–0.78) | <0.0001 | ||