Table 4.

Standardized coefficients, standard errors, p-values, and R${}^2$ from the “univariate” linear regression models relating all seven quantitative emphysema metrics investigated to each of the seven clinical characteristics of interest.

	Standardized coefficient	S.E.	p-value	R${}^2$
%GT
%LAA	0.194	0.005	1.0 x ${10}^{-147}$	0.778
D	− 0.131	0.009	1.8 x ${10}^{-37}$	0.441
NJC	0.199	0.005	6.5 x ${10}^{-158}$	0.796
ACS	0.199	0.004	7.8 x ${10}^{-186}$	0.839
NC	0.137	0.008	2.6 x ${10}^{-54}$	0.514
%-Diffuse	− 0.155	0.008	6.6 x ${10}^{-68}$	0.566
ACA	0.166	0.007	2.5 x ${10}^{-89}$	0.638
FEV${}_1$/FVC
%LAA	− 0.153	0.006	6.5 x ${10}^{-96}$	0.585
D	0.133	0.008	2.4 x ${10}^{-49}$	0.400
NJC	− 0.160	0.006	1.1 x ${10}^{-106}$	0.619
ACS	− 0.166	0.005	3.7 x ${10}^{-130}$	0.684
NC	− 0.100	0.007	1.6 x ${10}^{-35}$	0.330
%-Diffuse	0.132	0.007	3.2 x ${10}^{-61}$	0.454
ACA	− 0.132	0.007	4.4 x ${10}^{-63}$	0.462
FEV${}_1$
%LAA	− 0.612	0.033	1.2 x${10}^{-59}$	0.542
D	0.574	0.041	3.1 x${10}^{-39}$	0.462
NJC	− 0.645	0.033	1.8 x ${10}^{-66}$	0.566
ACS	− 0.692	0.030	2.2 x ${10}^{-85}$	0.626
NC	− 0.373	0.038	2.8 x ${10}^{-21}$	0.380
%-Diffuse	0.502	0.037	3.1 x ${10}^{-36}$	0.449
ACA	− 0.520	0.036	5.7 x ${10}^{-40}$	0.465
FRC
%LAA	0.735	0.039	4.7 x ${10}^{-62}$	0.590
D	− 0.530	0.051	2.2 x ${10}^{-23}$	0.434
NJC	0.764	0.038	2.6 x ${10}^{-67}$	0.608
ACS	0.803	0.034	1.6 x ${10}^{-84}$	0.660
NC	0.492	0.045	2.8 x ${10}^{-25}$	0.443
%-Diffuse	− 0.585	0.045	2.8 x ${10}^{-34}$	0.483
ACA	0.639	0.042	1.9 x ${10}^{-44}$	0.525
FRC/TLC
%LAA	0.061	0.005	4.3 x ${10}^{-35}$	0.337
D	− 0.054	0.005	3.4 x ${10}^{-21}$	0.256
NJC	0.064	0.005	2.1 x ${10}^{-38}$	0.355
ACS	0.071	0.004	1.1 x ${10}^{-52}$	0.428
NC	0.037	0.005	1.2 x ${10}^{-12}$	0.202
%-Diffuse	− 0.051	0.005	6.5 x ${10}^{-23}$	0.267
ACA	0.055	0.005	1.8 x ${10}^{-27}$	0.294
SGRQ (Total)
%LAA	13.276	0.953	2.7 x ${10}^{-38}$	0.261
D	− 13.651	1.095	9.5 x ${10}^{-32}$	0.222
NJC	14.078	0.944	7.8 x ${10}^{-43}$	0.287
ACS	15.444	0.873	2.4 x ${10}^{-56}$	0.359
NC	7.148	1.032	1.1 x ${10}^{-11}$	0.088
%-Diffuse	− 11.039	1.020	5.6 x ${10}^{-25}$	0.179
ACA	11.642	0.997	2.0 x ${10}^{-28}$	0.201
6MWD
%LAA	− 169.800	16.441	6.0 x ${10}^{-23}$	0.243
D	166.934	18.829	1.1 x ${10}^{-17}$	0.209
NJC	− 180.141	16.477	2.8 x ${10}^{-25}$	0.258
ACS	− 211.532	15.917	4.3 x ${10}^{-35}$	0.317
NC	− 92.191	16.845	6.8 x ${10}^{-08}$	0.142
%-Diffuse	137.284	17.187	8.3 x ${10}^{-15}$	0.190
ACA	− 150.377	17.078	1.8 x ${10}^{-17}$	0.208

LAA low attenuation area, NJC normalized join-count, ACS average cluster size, NC number of cluster, ACA average cluster area, FEV${}_1$ forced expiratory volume in one second, FVC forced vital capacity, 6MWD 6-minute walk distance, FRC functional residual capacity, TLC total lung capacity, GT gas trapping.