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. 2023 Aug 24;13:13880. doi: 10.1038/s41598-023-41136-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The evaluation of systemic toxicity of nanoghost (NP) and nanoparticle (NG) (100 μL of NP and NG containing 6 μg of GL) for NG/NP treated rabbits, compared to control groups upon weigh tracking for a month (n = 8 for each group, P-value < 0.05). (B) The in vivo GL profile of drug-loaded NG and PLGA NPs in the pharmacokinetic study. 100 μL of NP and NG containing 2.88 μg of GL was injected intravenously. Data represent mean ± SD (n = 3).