Table 2.
Systemic treatments received prior to palbociclib initiation.
| Overall population (n = 191) | |
|---|---|
| Chemotherapy | |
| Number of lines of prior chemotherapy for metastatic disease, median (range) (n = 29) | 1.0 (1.0–3.0) |
| Patients treated with neoadjuvant chemotherapy, n (%) | |
| Yes | 23 (12%) |
| No | 168 (88%) |
| Patients treated with adjuvant chemotherapy, n (%) | |
| Yes | 67 (35%) |
| No | 124 (65%) |
| Chemotherapy for advanced/metastatic, n (%) | |
| Yes | 29 (15%) |
| No | 162 (85%) |
| Hormone therapy | |
| Number of lines of prior hormone therapy for metastatic disease, median (range) (n = 74) | 1.0 (1.0-4.0) |
| Neoadjuvant hormone therapy, n (%) | |
| Yes | 7 (4%) |
| No | 184 (96%) |
| Adjuvant hormone therapy, n (%) | |
| Yes | 110 (58%) |
| No | 81 (42%) |
| Hormone therapy for advanced/metastatic, n (%) | |
| Yesa | 73 (38%) |
| No | 118 (62%) |
| Type of hormone therapy, n (%) | |
| Neoadjuvant | |
| Anastrozole/letrozole | 4 (2%) |
| Tamoxifen | 3 (2%) |
| Adjuvant | |
| Anastrozole/letrozole | 33 (17%) |
| Exemestane | 11 (6%) |
| Tamoxifen | 84 (44%) |
| Goserelin only | 2 (1%) |
| Goserelin with Anastrozole | 1 (1%) |
| Goserelin with Letrozole | 1 (1%) |
| Goserelin with Tamoxifen, then Exemestane | 1 (1%) |
| Metastatic setting | |
| Anastrozole/letrozole | 46 (24%) |
| Exemestane | 12 (6%) |
| Fulvestrant | 3 (2%) |
| Tamoxifen | 12 (6%) |
| Goserelin only | 2 (1%) |
| Goserelin with letrozole | 9 (5%) |
| Goserelin with exemestane, letrozole and tamoxifen | 1 (1%) |
aIncludes any patient, regardless of treatment line, with at least one hormone therapy recorded as being in the advanced/disease modifying/metastatic setting. Standard imputation of data was required for the date chemotherapy was started (27 instances [19 instances with only year recorded, 8 instances with only month and year recorded]) and stopped (28 instances [11 instances with only year recorded, 17 instances with only month and year recorded]); hormone therapy was started (65 instances [33 instances with only year recorded, 32 instances with only month and year recorded]) and stopped (73 instances [34 instances with only year recorded, 39 instances with only month and year recorded]).