Table 3.
Multivariate survival analysis of HCC patients with low TBS undergoing surgical resection or transarterial chemoembolization (n = 319).
| Overall survival | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | CI | p | HR | CI | p | |
| Age (≦66/ > 66 years) | 1.794 | 1.381–2.330 | < 0.001 | 1.517 | 1.151–2.000 | 0.003 |
| Sex (male/female) | 0.799 | 0.581–1.044 | 0.095 | |||
| HBsAg (negative/positive) | 0.859 | 0.664–1.112 | 0.249 | |||
| Anti-HCV (negative/positive) | 1.442 | 1.105–1.880 | 0.007 | |||
| Albumin level (≥ 3.5/ < 3.5 g/dL) | 2.390 | 1.771–3.225 | < 0.001 | |||
| Bilirubin level (≦1.1/ > 1.1 mg/dL) | 1.330 | 1.014–1.746 | 0.040 | |||
| ALT (≦40/ > 40 IU/L) | 0.944 | 0.727–1.226 | 0.664 | |||
| Creatinine (≦1.1/ > 1.1 mg/dL) | 1.330 | 1.002–1.766 | 0.048 | |||
| Platelet (≥ 150,000/ < 150,000/μL) | 1.528 | 1.172–1.992 | 0.002 | |||
| INR of PT (≦1.0/ > 1.0) | 0.762 | 0.574–1.010 | 0.059 | |||
| AFP (≦200/ > 200 ng/mL) | 1.450 | 1.086–1.937 | 0.012 | 1.811 | 1.345–2.439 | < 0.001 |
| Performance status 0–1/2–4 | 2.270 | 1.541–3.342 | < 0.001 | 1.888 | 1.264–2.822 | 0.002 |
| ALBI grade 1/grade2–3 | 1.949 | 1.494–2.543 | < 0.001 | 1.738 | 1.317–2.294 | < 0.001 |
| Vascular invasion (no/yes) | 1.892 | 1.641–2.181 | < 0.001 | 1.537 | 1.102–2.142 | 0.011 |
| SR versus TACE | 2.134 | 1.615–2.820 | < 0.001 | 1.683 | 1.246–2.274 | < 0.001 |
The forepart of the parentheses was set as the reference group in the univariate and multivariate analysis.
AFP ɑ-fetoprotein, ALBI albumin-bilirubin, ALT alanine aminotransferase, INR of PT international normalized ratio of prothrombin time, SR surgical resection, TACE transarterial chemoembolization, TBS tumor burden score.