Table 5.
Multivariate survival analysis in HCC patients with high TBS undergoing surgical resection or transarterial chemoembolization (n = 299).
| Overall survival | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | CI | p | HR | CI | p | |
| Age (≦66/ > 66 years) | 0.975 | 0.758–1.255 | 0.845 | |||
| Sex (male/female) | 0.891 | 0.631–1.258 | 0.512 | |||
| HBsAg (negative/positive) | 0.998 | 0.774–1.285 | 0.249 | |||
| Anti-HCV (negative/positive) | 0.968 | 0.693–1.353 | 0.850 | |||
| Albumin level (≥ 3.5/ < 3.5 g/dL) | 1.567 | 1.201–2.044 | 0.001 | |||
| Bilirubin level (≦1.1/ > 1.1 mg/dL) | 1.536 | 1.155–2.043 | 0.003 | |||
| ALT (≦40/ > 40 IU/L) | 0.937 | 0.727–1.208 | 0.617 | |||
| Creatinine (≦1.1/ > 1.1 mg/dL) | 1.330 | 1.018–1.738 | 0.036 | |||
| Platelet (≥ 150,000/ < 150,000/μL) | 0.986 | 0.677–1.436 | 0.942 | |||
| INR of PT (≦1.0/ > 1.0) | 1.557 | 1.197–2.025 | 0.001 | |||
| AFP (≦200/ > 200 ng/mL) | 1.528 | 1.188–1.966 | 0.001 | 1.483 | 1.150–1.913 | 0.002 |
| Performance status 0–1/2–4 | 1.638 | 1.212–2.215 | < 0.001 | |||
| ALBI grade 1/grade2-3 | 1.570 | 1.215–2.030 | 0.001 | 1.428 | 1.100–1.855 | 0.007 |
| Vascular invasion (no/yes) | 1.722 | 1.340–2.214 | < 0.001 | 1.499 | 1.160–1.938 | 0.002 |
| SR vs TACE | 2.826 | 2.161–3.695 | < 0.001 | 2.580 | 1.964–3.390 | < 0.001 |
The forepart of the parentheses was set as the reference group in the univariate and multivariate analysis.
AFP ɑ-fetoprotein, ALBI albumin-bilirubin, ALT alanine aminotransferase, INR of PT international normalized ratio of prothrombin time, SR surgical resection, TACE transarterial chemoembolization, TBS tumor burden score.