Fig. 1. Study design and clinical efficacy analysis.
a Study design: patients were given pembrolizumab on day 1 of each cycle, and pelareorep on days 1, 2,3 and 8 of cycle 1 and days 1 and 8 of cycle 2 onwards. Blood and tissue biopsies were collected (as indicated) for molecular response analysis to treatment. b Swimmer plot of best responses of the 13 patients on the trial. c Progression Free Survival and d Overall Survival.