Fig. 1.

Time courses of mean observed hepatic HSD-1 inhibition and mean individual model-predicted SPI-62 plasma concentrations following 0.2, 0.4, 0.7, and 2 mg oral multiple doses of SPI-62. Vertical black lines represent the start and stop of multiple doses. For subjects who received 0.2 mg SPI-62, a loading dose of 3 mg was administered. For subjects who received 0.7 mg or 2 mg, a single dose of SPI-62 was followed by a 6-day washout before the start of the QD dose regimens. QD once daily