Table 2.
Primary outcomes of TKA with IPACK block supplementation
| Outcomes | Number of trials | Total number of participants | WMD or SMD, [95% CI] | p value for overall effect | Heterogeneity | Model | |||
|---|---|---|---|---|---|---|---|---|---|
| Tau2 | χ2 | I2 (%) | |||||||
| IPACK | Control | ||||||||
| Rest pain scores at specific time points | |||||||||
| POH 8–12 | 12 | 542 | 543 | − 0.85 [− 1.36, − 0.34] | 0.001 | 0.76 | 172.01 | 94 | Random |
| POD1 | 12 | 517 | 518 | − 0.49 [− 0.85, − 0.14] | 0.006 | 0.34 | 84.79 | 87 | Random |
| POD2 | 12 | 523 | 533 | − 0.28 [− 0.51, − 0.05] | 0.02 | 0.12 | 38.60 | 72 | Random |
| POD3 or discharge | 5 | 215 | 215 | − 0.14 [− 0.33, 0.05] | 0.14 | NA | 3.98 | 0 | Fixed |
| Dynamic pain scores at specific time points | |||||||||
| POH 8–12 | 9 | 366 | 366 | − 0.52 [− 0.92, − 0.12] | 0.01 | 0.32 | 56.20 | 86 | Random |
| POD1 | 12 | 495 | 493 | − 0.49 [− 0.87, − 0.11] | 0.01 | 0.40 | 94.41 | 88 | Random |
| POD2 | 9 | 347 | 356 | − 0.29 [− 0.63, 0.05] | 0.09 | 0.21 | 40.00 | 80 | Random |
| POD3 or discharge | 5 | 215 | 215 | − 0.45 [− 0.92, 0.02] | 0.06 | 0.24 | 23.30 | 83 | Random |
| Opioid consumption | |||||||||
| Within 24 h | 10 | 402 | 400 | − 0.76 [− 1.13, − 0.39] | < 0.00001 | 0.30 | 58.13 | 85 | Random |
| 24–48 h | 7 | 274 | 273 | − 0.43 [− 0.85, − 0.01] | 0.04 | 0.26 | 34.89 | 83 | Random |
| Total opioid consumption | 8 | 341 | 343 | − 0.64 [− 1.07, − 0.22] | 0.003 | 0.32 | 51.16 | 86 | Random |
POH postoperative hour(s); POD postoperative day; IPACK interspace between the popliteal artery and capsule of the posterior knee block; TKA total knee arthroplasty; WMD weighted mean difference; SMD standardized mean difference; CI confidence interval