Table 5.

Pharmacokinetic parameters of difelikefalin and metabolites in plasma (pooled samples by time point)

Healthy subjects
Parameter	Difelikefalin	MP1	MP2	MP3	MP4
tmax (h)	0.083	0.083	0.083	0.083	0.083
Cmax (ng-eq/mL)	23.8	0.356	0.170	0.280	0.140
AUClast (h*ng-eq/mL)	30.3	0.145
AUClast (% total)	99.52	0.48

Subjects on hemodialysis
Parameter	Difelikefalin	MP1	MP2	MP3	MP4
tmax (h)	0.083	0.083		0.083
Cmax (ng-eq/mL)	24.7	0.548		0.340
AUClast (h*ng-eq/mL)	283	0.271		0.0634
AUClast (% total)	99.88	0.10		0.02

AUC_last area under the curve from time 0 h to last quantifiable concentration, C_max maximum concentration, t_max time to reach C_max