Table 6.

Relative amounts of difelikefalin and metabolites in urine (% of dose excreted)

		% of dose excreted
	Collection interval	Difelikefalin	MU1	MU2	MU3	MU4	Total
Healthy subjects	0–4 h	52.6	–	0.499	0.715	0.434
	4–8 h	12.4	–	–	–	–
	8–12 h	5.62	–	–	–	–
	12–24 h	3.88	–	–	–	–
	Total	75.2	–	0.499	0.715	0.434	76.8
Subjects on hemodialysis	0–24 h	5.39	0.115	0.0697	–	–
	24–48 h	2.91	–	–	–	–
	48–72 h	1.99	–	–	–	–
	72–96 h	1.25	–	–	–	–
	96–120 h	0.697	–	–	–	–
	Total	12.2	0.115	0.0697	–	–	12.4