Table 7.
Relative amounts of difelikefalin and metabolites in feces (% of dose excreted)
| % of dose excreted | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Collection interval | Difelikefalin | MF1 | MF2 | MF3 | MF4 | MF5 | MF6 | MF7 | MF8 | MF9 | Total | |
| Healthy subjects | 24–48 h | 3.37 | – | – | – | – | – | – | – | – | – | |
| 48–72 h | 3.35 | – | – | – | 0.299 | 0.267 | – | – | – | – | ||
| 72–96 h | 3.39 | – | – | – | – | – | – | – | – | – | ||
| 96–120 h | 1.59 | – | – | – | 0.250 | – | – | – | – | – | ||
| Total | 11.7 | – | – | – | 0.550 | 0.267 | – | – | – | – | 12.5 | |
| Subjects on hemodialysis | 24–48 h | 9.00 | 0.592 | – | – | 0.560 | 0.372 | – | 0.350 | – | – | |
| 48–72 h | 2.17 | 0.0982 | – | – | 0.106 | 0.197 | – | 0.093 | – | – | ||
| 72–96 h | 13.6 | 0.522 | 0.187 | 0.270 | 0.742 | 0.702 | 0.228 | 0.441 | 0.187 | 0.252 | ||
| 96–120 h | 10.1 | – | – | – | 0.596 | 0.709 | – | – | – | – | ||
| 120–144 h | 9.83 | 0.811 | – | – | – | 0.463 | – | 1.387 | – | – | ||
| 144–168 h | 2.75 | – | – | – | – | – | – | – | – | – | ||
| 168–192 h | 7.60 | – | – | – | – | – | – | – | – | – | ||
| Total | 55.1 | 2.02 | 0.187 | 0.270 | 2.00 | 2.44 | 0.228 | 2.27 | 0.187 | 0.252 | 64.9 | |