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. 2023 Aug 23;11(8):e007082. doi: 10.1136/jitc-2023-007082

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Enhanced antigen cross-presentation in cDC2s upon ISCOMs. (A) HA-1- specific CD8⁺ T-cell expansion indicated by double-positive HA-1 tetramer staining (in red) for cDC1s and cDC2s after stimulation with short peptide, long peptide, or ISCOMS+ long peptide. DCs (100,000 cells) were incubated with PBMCs (750,000 cells) in a 1:7.5 ratio. Representative flow cytometry data are shown from one healthy DC donor. (B) Fold expansion of HA-1-specific CD8⁺ T cells in cDC2s and cDC1s. The numbers of different healthy DC donors used are depicted in the graphs. Statistical analyses were done using paired non-parametric t-test. *p<0.05. cDC1, conventional type 1 DC; cDC2, conventional type 2 DC; ISCOMs, immune stimulatory complexes; PBMCs, peripheral blood mononuclear cells.