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. 2023 Aug 10;11:1207520. doi: 10.3389/fbioe.2023.1207520

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Copyright © 2023 Liang, Zhang, Zhang, Luan, Li, Xiang, Jing and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) In vitro cumulative release curves of free RPT, RPT/PLGA–PEG NPs and RPT/TC–PLGA–PEG NPs. (B) Bone mineral binding ability. (C) Cytotoxicity studies of drug loaded NPs on rabbit bone marrow mesenchyml stem cell. Note: ***p < 0.001 compared with the negative control. (D) Cytotoxicity studies of blank NPs on rabbit bone marrow mesenchyml stem cell. Note: ***p < 0.001 compared with the negative control. (E) Haemolytic toxicity of various concentrations of NPs.