TABLE 3.
Pharmacokinetic parameters in different groups.
| RPT | RPT/PLGA-PEG NPs | RPT/TC-PLGA-PEG NPs | |
|---|---|---|---|
| Cmax (μg/mL) | 11.18 ± 0.82 | 14.84 ± 0.63 | 12.21 ± 0.66 |
| T max (h) | 0.0830 ± 0.00 | 0.0830 ± 0.00 | 0.0830 ± 0.00 |
| t 1/2 (h) | 20.05 ± 5.38 | 41.44 ± 8.09 | 32.68 ± 6.7 |
| AUC0–∞ (μg/mL h) | 190.65 ± 15.29 | 590.78 ± 83.30 | 419.15 ± 73.13 |
| MRT (h) | 24.61 ± 5.25 | 57.78 ± 9.99 | 46.76 ± 8.69 |
Abbreviations: TC, tetracycline; PLGA, poly-d,l-lactide-co-glycolide; PEG, poly ethylene glycol; NPs, nanoparticles; Cmax, maximum concentration; T max, time to reach peak plasma concentration; t 1/2, half life; AUC0–∞, area under the curve from 0 to ∞; MRT, mean residence time.