Table 2.
Frequency of COVID-19 clinical manifestations, trend of symptoms’ changes from the Parental to the Omicron waves, and symptoms duration in the study population (N = 509), overall and according to the different VOC.
| Overall (N = 509) | Parental (N = 387) | Delta (N = 52) | Omicron (N = 70) | p-valuea | p-Trenda | |
|---|---|---|---|---|---|---|
| Symptoms, N (%) | ||||||
| Rhinitis | 105 (20.63) | 62 (16.02) | 17 (32.69) | 26 (37.14) | <0.0001 | < 0.0001 |
| Cough | 75 (14.73) | 37 (9.56) | 14 (26.92) | 24 (34.29) | <0.0001 | < 0.0001 |
| Dyspnea | 7 (1.38) | 5 (1.29) | 0 (0) | 2 (2.86) | 0.1010 | 0.4687 |
| Fever | 238 (46.76) | 158 (40.83) | 27 (51.92) | 53 (75.71) | <0.0001 | < 0.0001 |
| Otalgia | 2 (0.39) | 1 (0.26) | 1 (1.92) | 0 (0) | 0.1557 | 0.8075 |
| Myalgia | 21 (4.13) | 14 (3.62) | 2 (3.85) | 5 (7.14) | 0.0275 | 0.2031 |
| Arthralgia | 15 (2.95) | 13 (3.36) | 0 (0) | 2 (2.86) | 0.0558 | 0.5428 |
| Sore throat | 28 (5.50) | 17 (4.39) | 1 (1.92) | 10 (14.29) | 0.0004 | 0.0045 |
| Hyposmia and/or ageusia | 46 (9.04) | 38 (9.82) | 5 (9.62) | 3 (4.29) | 0.3277 | 0.1691 |
| Conjunctivitis | 12 (2.36) | 10 (2.58) | 1 (1.92) | 1 (1.43) | 0.1213 | 0.5323 |
| Fatigue | 79 (15.52) | 55 (14.21) | 9 (17.31) | 15 (21.43) | 0.2871 | 0.1148 |
| Headache | 80 (15.72) | 56 (14.47) | 8 (15.38) | 16 (22.86) | 0.2068 | 0.0939 |
| Alteration of consciousness | 0 (0) | 0 (0) | 0 (0) | 0 (0) | – | – |
| Abdominal pain | 15 (2.95) | 13 (3.36) | 1 (1.92) | 1 (1.43) | 0.0841 | 0.3293 |
| Nausea/vomiting | 23 (4.52) | 16 (4.13) | 2 (3.85) | 5 (7.14) | 0.0338 | 0.3206 |
| Diarrhea | 39 (7.66) | 31 (8.01) | 4 (7.69) | 4 (5.71) | 0.8018 | 0.5270 |
| Poor feeding | 20 (3.93) | 15 (3.88) | 1 (1.92) | 4 (5.71) | 0.0472 | 0.6419 |
| Lymphadenopathy | 1 (0.20) | 1 (0.26) | 0 (0) | 0 (0) | 0.7603 | 0.5970 |
| Skin rash | 12 (2.36) | 11 (2.84) | 1 (1.92) | 0 (0) | 0.0594 | 0.1491 |
| Pneumonia | 3 (0.59) | 2 (0.52) | 0 (0) | 1 (1.43) | 0.2393 | 0.4814 |
| Other symptomsb | 35 (6.88) | 28 (7.24) | 2 (3.85) | 5 (7.14) | 0.0348 | 0.7681 |
| Symptoms duration, days | 3 (1–6) | 3 (1–6) | 2.5 (2–7) | 2.5 (1–4) | 0.2499 | |
a
–χ2 or Fisher as appropriated.
b
“Other symptoms” included elevation of body temperature between 37 and 37.4°C, tachycardia, chest pain, restlessness, vertigo, photophobia, and chilblains.