Table 4.
Clinical features of COVID-19 between children who were up-to-date vaccinated and those who were not, overall, and stratified according to the VOC.
| Vaccinations | Overall (N = 496) | p-value | Parental (N = 387) | Delta (N = 52) | Omicron (N = 70) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Non primary | Primary | Non primary | Primary | Non primary | Primary | Non primary | Primary | ||
| Symptoms, N (%) | |||||||||
| Rhinitis | 18 (23.38) | 82 (19.57) | 0.4442 | 10 (18.52) | 48 (14.91) | 3 (50) | 14 (31.11) | 5 (29.41) | 20 (38.46) |
| Cough | 14 (18.18) | 59 (14.08) | 0.3506 | 7 (12.96) | 29 (9.01) | 3 (50) | 11 (24.44) | 4 (23.53) | 19 (36.54) |
| Dyspnea | 1 (1.3) | 5 (1.19) | 0.4033 | 1 (1.85) | 3 (0.93) | 0 (0) | 0 (0) | 0 (0) | 2 (3.85) |
| Fever | 41 (53.25) | 187 (44.63) | 0.1632 | 26 (48.15) | 123 (38.2) | 2 (7.41) | 25 (55.56) | 13 (76.47) | 39 (75) |
| Otalgia | 0 (0) | 2 (0.48) | 0.7134 | 0 (0) | 1 (0.31) | 0 (0) | 1 (2.22) | 0 (0) | 0 (0) |
| Myalgia | 1 (1.3) | 20 (4.77) | 0.1082 | 0 (0) | 14 (4.35) | 0 (0) | 2 (4.44) | 1 (5.88) | 4 (7.69) |
| Arthralgia | 3 (3.9) | 12 (2.86) | 0.2283 | 3 (5.56) | 10 (3.11) | 0 (0) | 0 (0) | 0 (0) | 2 (3.85) |
| Sore throat | 4 (5.19) | 24 (5.73) | 0.2129 | 2 (3.7) | 15 (4.66) | 0 (0) | 1 (2.22) | 2 (11.76) | 8 (15.38) |
| Hyposmia and/or ageusia | 8 (10.39) | 38 (9.07) | 0.1517 | 6 (11.11) | 32 (9.94) | 1 (16.67) | 4 (8.89) | 1 (5.88) | 2 (3.85) |
| Conjunctivitis | 2 (2.6) | 9 (2.15) | 0.2939 | 2 (3.7) | 7 (2.17) | 0 (0) | 1 (2.22) | 0 (0) | 1 (1.92) |
| Fatigue | 7 (9.09) | 71 (16.95) | 0.0819 | 6 (11.11) | 49 (15.22) | 0 (0) | 9 (20) | 1 (5.88) | 13 (25) |
| Headache | 14 (18.18) | 66 (15.75) | 0.5941 | 8 (14.81) | 48 (14.91) | 3 (50) | 5 (11.11) | 3 (17.65) | 13 (25) |
| Alteration of consciousness | 0 (0) | 0 (0) | – | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Abdominal pain | 1 (1.3) | 14 (3.34) | 0.2182 | 1 (1.85) | 12 (3.73) | 0 (0) | 1 (2.22) | 0 (0) | 1 (1.92) |
| Nausea/vomiting | 3 (3.9) | 20 (4.77) | 0.2310 | 3 (5.56) | 13 (4.04) | 0 (0) | 2 (4.44) | 0 (0) | 5 (9.62) |
| Diarrhea | 11 (14.29) | 28 (6.68) | 0.0227 | 7 (12.96) | 24 (7.45) | 1 (16.67) | 3 (6.67) | 3 (17.65) | 1 (1.92) |
| Poor feeding | 3 (3.9) | 15 (3.58) | 0.2478 | 3 (5.56) | 10 (3.11) | 0 (0) | 1 (2.22) | 0 (0) | 4 (7.69) |
| Lymphadenopathy | 0 (0) | 1 (0.24) | 0.8448 | 0 (0) | 1 (0.31) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Skin rash | 1 (1.3) | 11 (2.63) | 0.2917 | 1 (1.85) | 10 (3.11) | 0 (0) | 1 (2.22) | 0 (0) | 0 (0) |
| Pneumonia | 0 (0) | 3 (0.72) | 0.6022 | 0 (0) | 2 (0.62) | 0 (0) | 0 (0) | 0 (0) | 1 (1.92) |
| Other symptoms | 10 (12.99) | 24 (5.73) | 0.0205 | 8 (14.81) | 19 (5.9) | 0 (0) | 2 (4.44) | 2 (11.76) | 3 (5.77) |
| Number of symptoms, N (%) | |||||||||
| 0 | 14 (18.18) | 124 (29.59) | 0.0550 | 12 (22.22) | 112 (34.78) | 2 (3.33) | 10 (22.22) | 0 (0) | 2 (3.85) |
| 1 | 22 (28.57) | 106 (25.3) | 17 (31.48) | 87 (27.02) | 0 (0) | 10 (22.22) | 5 (29.41) | 9 (17.31) | |
| 2 | 23 (29.87) | 78 (18.62) | 14 (25.93) | 52 (16.15) | 2 (33.33) | 12 (26.67) | 7 (41.18) | 14 (26.92) | |
| ≥3 | 18 (23.38) | 111 (26.49) | 11 (20.37) | 71 (22.05) | 2 (33.33) | 13 (28.89) | 5 (29.41) | 27 (51.92) | |
| Duration of symptoms | |||||||||
| Days | 3 (1–7) | 3 (1–6) | 0.4323 | 3 (2–7) | 3 (1–6) | 8 (2–14) | 2.5 (2–7) | 1 (0–3) | 3 (1–4) |