Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Thermodynamic cycle analysis of the free energy contributions of the HxGH and KMSKS catalytic signatures in Leucyl-tRNA synthetase and its 129-residue urzyme identify dramatic changes in the relative contributions of the KMSKS sequence and the HVGH*KMSKS two-way interaction. Structural analysis shows that a conserved network of non-polar packing in the anticodon binding domain functions as an “Enforcer” to impose coupled behavior in the full-length enzyme.
