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Binding affinities of the TFAP2A (aa 203–420) and TFAP2B (aa 219–457) disease-associated mutants to GCC(N3)GGC DNA
| Mutants | K d (nM) | |
|---|---|---|
| TFAP2A | WT | 19 ± 1 |
| R217S | ND | |
| R254W | WB | |
| R255G | WB | |
| G262E | 129 ± 22 | |
| TFAP2B | WT | 18 ± 2 |
| R236C | ND | |
| A275D | WB | |
| K276R | 382 ± 36 | |
| L284S | ND | |
| R285Q | 178 ± 43 | |
| R300C | 88 ± 20 | |
| V336I | 44 ± 9 |
The DNA sequence of one strand of the DNA duplex is GTGCCCGAGGCAG. ND: no detectable binding; WB: weak binding.
