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Model of the role of CasDinG in type IV-A CRISPR immunity. The type IV-A multi-subunit Csf crRNA-guided complex binds complementary dsDNA forming an R-loop to which CasDinG is recruited. CasDinG unwinds the dsDNA in a 5′-3′ manner, possibly distorting DNA structure and/or displacing RNA primers. The N-terminal domain of CasDinG likely interacts with dsDNA, but the exact role of the domain in type IV-A immunity remains unknown.
