Table 4.
Model-estimated fold-change from baseline in symptoms: Association with change in inflammatory marker.
| (ln)Physical Function | (ln)Pain | (ln)Attention/Concentration | (ln)Cognitive Problems | (ln)Fatigue | Sleep Insufficiency | (ln)Depression | |
|---|---|---|---|---|---|---|---|
| Fold-Change Estimate (95% Confidence Interval) |
|||||||
| JOINT MODEL 1 [Marker = sTNF-RII] | |||||||
| Per Unit Change from Baseline in (ln)sTNF-RII | |||||||
| If a Patient | 0.79 (0.73–0.85)* | 3.67 (1.64–8.20)* | 0.99 (0.92–1.07) | 0.98 (0.91–1.06) | 1.26 (0.73–2.18) | 0.70 (0.42–1.20) | 1.04 (0.96–1.13) |
| If a Control | 1.00 (0.84–1.19) | 0.64 (0.10–4.10) | 1.01 (0.83–1.23) | 0.96 (0.82–1.12) | 1.36 (0.39–4.78) | 0.99 (0.32–3.09) | 0.94 (0.81–1.10) |
| Per Unit of (ln)Symptom at Baseline | |||||||
| If a Patient | 0.69 (0.64–0.75) | 0.49 (0.45–0.54) | 0.85 (0.80–0.90) | 0.66 (0.61–0.72) | 0.51 (0.46–0.56) | 0.49 (0.45–0.53) | 0.56 (0.52–0.61) |
| If a Control | 0.89 (0.71–1.10) | 0.51 (0.42–0.60) | 0.69 (0.61–0.78) | 0.70 (0.61–0.81) | 0.75 (0.63–0.89) | 0.70 (0.60–0.82) | 0.55 (0.47–0.64) |
| Per Unit of (ln)Social Support at Same Visit | 1.08 (1.04–1.13) | 0.44 (0.28–0.71) | 1.06 (1.00–1.13) | 0.91 (0.88–0.95) | 0.54 (0.39–0.76) | 0.56 (0.42–0.75) | 0.86 (0.83–0.90) |
| General Change from Baseline, Any Visit | |||||||
| If a Patient | 0.92 (0.91–0.94) | 3.60 (2.90–4.46) | 1.01 (0.99–1.03) | 1.01 (0.99–1.03) | 0.72 (0.64–0.81) | 1.04 (0.93–1.17) | 0.96 (0.94–0.98) |
| If a Control |
1.01 (0.99–1.03) |
1.84 (1.29–2.62) |
1.05 (1.03–1.07) |
0.96 (0.94–0.98) |
0.63 (0.51–0.78) |
0.92 (0.76–1.12) |
0.92 (0.91–0.94) |
| JOINT MODEL 2 [Marker = IL-1RA] | |||||||
| Per Unit Change from Baseline in (ln)IL-1RA | |||||||
| If a Patient | 0.93 (0.90–0.97)* | 1.14 (0.74–1.75) | 1.00 (0.96–1.04) | 0.96 (0.92–1.00) | 0.84 (0.64–1.11) | 0.76 (0.58–1.00) | 0.97 (0.93–1.01) |
| If a Control | 1.03 (0.95–1.11) | 0.74 (0.34–1.59) | 0.97 (0.90–1.05) | 1.03 (0.97–1.09) | 0.71 (0.43–1.18) | 1.05 (0.66–1.68) | 1.03 (0.97–1.09) |
| Per Unit of (ln)Symptom at Baseline | |||||||
| If a Patient | 0.70 (0.65–0.76) | 0.50 (0.45–0.55) | 0.83 (0.76–0.89) | 0.66 (0.61–0.71) | 0.51 (0.46–0.56) | 0.49 (0.45–0.53) | 0.57 (0.52–0.61) |
| If a Control | 0.89 (0.71–1.10) | 0.50 (0.42–0.60) | 0.69 (0.60–0.79) | 0.70 (0.61–0.81) | 0.74 (0.62–0.88) | 0.70 (0.60–0.82) | 0.54 (0.46–0.64) |
| Per Unit of (ln)Social Support at Same Visit | 1.08 (1.04–1.13) | 0.43 (0.26–0.70) | 1.08 (1.02–1.15) | 0.91 (0.88–0.95) | 0.54 (0.39–0.75) | 0.56 (0.42–0.75) | 0.86 (0.83–0.90) |
| General Change from Baseline, Any Visit | |||||||
| If a Patient | 0.90 (0.89–0.92) | 3.74 (3.02–4.64) | 1.01 (0.99–1.03) | 1.01 (0.99–1.03) | 0.73 (0.65–0.82) | 1.02 (0.91–1.15) | 0.96 (0.94–0.98) |
| If a Control | 1.01 (0.99–1.03) | 1.82 (1.26–2.64) | 1.05 (1.03–1.07) | 0.96 (0.94–0.98) | 0.61 (0.49–0.76) | 0.92 (0.76–1.12) | 0.92 (0.91–0.94) |
| (ln)Physical Function | (ln)Pain | (ln)Attention/Concentration | (ln)Cognitive Problems | (ln)Fatigue | Sleep Insufficiency | (ln)Depression | |
|---|---|---|---|---|---|---|---|
| JOINT MODEL 3 [Marker = IL-6] | |||||||
| Per Unit Change from Baseline in (ln)IL-6 | |||||||
| In Patient or Control | 0.96 (0.94–0.98)* | 1.15 (0.91–1.46) | 1.02 (1.00–1.04) | 1.00 (0.98–1.02) | 1.02 (0.87–1.19) | 1.12 (0.95–1.31) | 1.01 (0.99–1.03) |
| Per Unit of (ln)Symptom at Baseline | |||||||
| If a Patient | 0.70 (0.65–0.76) | 0.50 (0.45–0.55) | 0.85 (0.79–0.92) | 0.66 (0.61–0.71) | 0.51 (0.46–0.56) | 0.49 (0.45–0.53) | 0.56 (0.52–0.61) |
| If a Control | 0.90 (0.72–1.11) | 0.51 (0.42–0.60) | 0.69 (0.60–0.79) | 0.70 (0.61–0.81) | 0.75 (0.63–0.89) | 0.70 (0.60–0.82) | 0.55 (0.47–0.64) |
| Per Unit of (ln)Social Support at Same Visit | 1.09 (1.05–1.14) | 0.41 (0.26–0.66) | 1.06 (1.00–1.13) | 0.91 (0.88–0.95) | 0.54 (0.39–0.76) | 0.57 (0.42–0.76) | 0.86 (0.83–0.90) |
| General Change from Baseline, Any Visit | |||||||
| If a Patient | 0.91 (0.90–0.93) | 3.63 (2.93–4.51) | 1.01 (0.99–1.03) | 1.01 (0.99–1.03) | 0.73 (0.65–0.82) | 1.02 (0.91–1.15) | 0.96 (0.94–0.98) |
| If a Control |
1.00 (0.98–1.02) |
1.86 (1.28–2.70) |
1.05 (1.03–1.07) |
0.96 (0.94–0.98) |
0.64 (0.52–0.80) |
0.94 (0.79–1.12) |
0.93 (0.91–0.95) |
| JOINT MODEL 4 [Marker = CRP] | |||||||
| Per Unit Change from Baseline in (ln)CRP | |||||||
| In Patient or Control | 0.99 (0.97–1.01) | 1.20 (1.02–1.40) | 0.99 (0.97–1.01) | 1.00 (0.98–1.02) | 0.98 (0.89–1.08) | 0.94 (0.85–1.04) | 1.00 (0.98–1.02) |
| Per Unit of (ln)Symptom at Baseline | |||||||
| If a Patient | 0.70 (0.65–0.75) | 0.50 (0.45–0.55) | 0.85 (0.80–0.90) | 0.66 (0.61–0.71) | 0.52 (0.47–0.57) | 0.50 (0.46–0.54) | 0.56 (0.52–0.61) |
| If a Control | 0.70 (0.55–0.91) | 0.50 (0.42–0.60) | 0.68 (0.60–0.78) | 0.70 (0.61–0.81) | 0.74 (0.61–0.90) | 0.70 (0.60–0.82) | 0.55 (0.47–0.64) |
| Per Unit of (ln)Social Support at Same Visit | 1.08 (1.04–1.13) | 0.44 (0.27–0.72) | 1.05 (0.99–1.11) | 0.91 (0.88–0.95) | 0.54 (0.39–0.76) | 0.57 (0.42–0.76) | 0.86 (0.83–0.90) |
| General Change from Baseline, Any Visit | |||||||
| If a Patient | 0.90 (0.89–0.92) | 3.86 (3.11–4.79) | 1.01 (0.99–1.03) | 1.01 (0.99–1.03) | 0.73 (0.65–0.82) | 1.03 (0.92–1.16) | 0.96 (0.94–0.98) |
| If a Control | 1.00 (0.96–1.04) | 1.92 (1.32–2.78) | 1.05 (1.03–1.07) | 0.96 (0.94–0.98) | 0.63 (0.50–0.78) | 0.92 (0.76–1.12) | 0.92 (0.91–0.94) |
The t statistic was used to assess the hypothesized associations between marker change and symptom change, evaluating the fold change shown against the null hypothesis of no change.
* Hypothesized association with p < 0.01. When associations with p < 0.01 are accepted as significant, the Table's overall False Discovery Rate remains below 5%.
Note: These models were not improved by adjusting for the timing of follow-up visits or for any other demographic or socioeconomic characteristics.