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. 2023 Jul 29;26(9):107497. doi: 10.1016/j.isci.2023.107497

Table 2.

TWAS-identified shared gene-tissue pairs between COVID-19 and female-specific cancers after conditional and joint analysis

Gene Tissue Type CHR No. SNPs Female-specific cancer
 COVID-19
Type BEST. GWAS.ID Z pBonferroni Subtype BEST. GWAS.ID Z pBonferroni
Breast cancer and COVID-19
 GBAP1 Adrenal Gland 1 328 BC rs4971059 −6.73 3.89 × 10−6 Infection rs11264339 7.05 4.06 × 10−7
 GBAP1 Artery Aorta 1 328 BC rs4971059 −6.49 1.96 × 10−5 Infection rs11264339 7.24 1.04 × 10−7
 GBAP1 Artery Coronary 1 328 BC rs4971059 −5.68 3.10 × 10−3 Infection rs11264339 7.09 3.02 × 10−7
 GBAP1 Artery Tibial 1 328 BC rs4971059 −6.30 7.05 × 10−5 Infection rs11264339 6.97 7.24 × 10−7
 GBAP1 Cells Transformed fibroblasts 1 328 BC rs4971059 −6.44 2.72 × 10−5 Infection rs11264339 7.13 2.34 × 10−7
 GBAP1 Esophagus Muscularis 1 328 BC rs4971059 −6.71 4.68 × 10−6 Infection rs11264339 6.80 2.39 × 10−6
 GBAP1 Heart Atrial Appendage 1 328 BC rs4971059 −5.68 3.10 × 10−3 Infection rs11264339 7.09 3.02 × 10−7
 GBAP1 Skin Not Sun Exposed Suprapubic 1 328 BC rs4971059 −6.84 1.79 × 10−6 Infection rs11264339 7.00 5.92 × 10−7
 GBAP1 Skin Sun Exposed Lower leg 1 328 BC rs4971059 −6.62 8.19 × 10−6 Infection rs11264339 7.05 4.04 × 10−7
 ABO Whole Blood 9 595 BC rs495828 −5.34 2.15 × 10−2 Infection rs612169 −10.05 2.24 × 10−18
 KANSL1-AS1 Artery Coronary 17 29 BC rs17763086 −6.03 3.93 × 10−4 Hospitalization rs8072451 −7.57 8.91 × 10−9
 KANSL1-AS1 Brain Anterior cingulate cortex BA24 17 29 BC rs17763086 −6.03 3.93 × 10−4 Hospitalization rs8072451 −7.57 8.91 × 10−9
 RP11-259G18.1 Brain Cortex 17 66 BC rs17763086 −6.03 3.93 × 10−4 Hospitalization rs8072451 −7.57 8.91 × 10−9
 CRHR1-IT1 Stomach 17 93 BC rs17763086 −6.03 3.93 × 10−4 Hospitalization rs8072451 −7.57 8.91 × 10−9
 RPS26P8 Pituitary 17 106 BC rs17763086 −6.03 3.93 × 10−4 Hospitalization rs8072451 −7.57 8.91 × 10−9
 RP11-707O23.5 Artery Tibial 17 111 BC rs17763086 −6.15 1.77 × 10−4 Hospitalization rs8072451 −7.87 7.98 × 10−10
 RP11-707O23.5 Brain Hypothalamus 17 111 BC rs17763086 −6.03 3.72 × 10−4 Hospitalization rs8072451 −7.58 7.84 × 10−9
 LRRC37A4P Adrenal Gland 17 138 BC rs17763086 6.03 3.93 × 10−4 Hospitalization rs8072451 7.57 8.91 × 10−9
 LRRC37A4P Heart Left Ventricle 17 138 BC rs17763086 6.07 3.05 × 10−4 Hospitalization rs8072451 7.65 4.79 × 10−9
 ABO Whole Blood 9 595 BC rs495828 −5.34 2.15 × 10−2 Hospitalization rs657152 −5.70 2.80 × 10−3
 RP11-707O23.5 Artery Tibial 17 111 BC rs17763086 −6.15 1.77 × 10−4 Critical illness rs16940665 −7.59 7.13 × 10−9
 RP11-707O23.5 Brain Hypothalamus 17 111 BC rs17763086 −6.03 3.72 × 10−4 Critical illness rs16940665 −7.40 3.10 × 10−8
 LRRC37A4P Brain Nucleus accumbens basal ganglia 17 138 BC rs17763086 6.03 3.82 × 10−4 Critical illness rs16940665 7.45 2.13 × 10−8
 MSTO2P Muscle Skeletal 1 236 BC rs11264372 −6.45 2.65 × 10−5 Critical illness rs11803917 −5.70 2.73 × 10−3
 MSTO2P Pancreas 1 236 BC rs11264372 −6.28 7.94 × 10−5 Critical illness rs11803917 −5.43 1.32 × 10−2
 HCN3 Brain Nucleus accumbens basal ganglia 1 298 BC rs4971059 −7.75 2.13 × 10−9 Critical illness rs35154152 −5.38 1.73 × 10−2
 GBAP1 Brain Cerebellum 1 328 BC rs4971059 −7.01 5.75 × 10−7 Critical illness rs35154152 −5.44 1.23 × 10−2
 MUC1 Pancreas 1 339 BC rs4971059 6.47 2.24 × 10−5 Critical illness rs35154152 5.25 3.59 × 10−2
 ABO Whole Blood 9 595 BC rs495828 −5.34 2.15 × 10−2 Critical illness rs657152 −5.57 5.98 × 10−3
Epithelial ovarian cancer and COVID-19
 ABO Artery Aorta 9 595 EOC rs495828 5.60 4.92 × 10−3 Infection rs612169 17.33 6.75 × 10−62
 KANSL1-AS1 Brain Anterior cingulate cortex BA24 17 29 EOC rs4566211 7.08 3.35 × 10−7 Hospitalization rs8072451 −7.57 8.91 × 10−9
 KANSL1-AS1 Vagina 17 29 EOC rs4566211 7.10 2.87 × 10−7 Hospitalization rs8072451 −7.54 1.05 × 10−8
 RP11-259G18.2 Small Intestine Terminal Ileum 17 59 EOC rs4566211 7.16 1.82 × 10−7 Hospitalization rs8072451 −7.58 7.80 × 10−9
 CRHR1-IT1 Artery Aorta 17 93 EOC rs17631676 7.11 2.66 × 10−7 Hospitalization rs8072451 −7.55 9.99 × 10−9
 CRHR1-IT1 Prostate 17 93 EOC rs17631676 7.10 2.87 × 10−7 Hospitalization rs8072451 −7.54 1.05 × 10−8
 RPS26P8 Breast Mammary Tissue 17 106 EOC rs17631676 7.08 3.35 × 10−7 Hospitalization rs8072451 −7.57 8.91 × 10−9
 RPS26P8 Pituitary 17 106 EOC rs17631676 7.08 3.35 × 10−7 Hospitalization rs8072451 −7.57 8.91 × 10−9
 LRRC37A4P Adrenal Gland 17 138 EOC rs17631676 −7.08 3.35 × 10−7 Hospitalization rs8072451 7.57 8.91 × 10−9
 PLEKHM1 Brain Cortex 17 162 EOC rs17631676 7.25 9.99 × 10−8 Hospitalization rs8072451 −5.19 5.00 × 10−2
 ABO Artery Aorta 9 595 EOC rs495828 5.60 4.92 × 10−3 Hospitalization rs657152 8.79 3.49 × 10−13
 KANSL1-AS1 Pancreas 17 29 EOC rs4566211 7.12 2.61 × 10−7 Critical illness rs16940665 −7.42 2.83 × 10−8
 KANSL1-AS1 Vagina 17 29 EOC rs4566211 7.10 2.87 × 10−7 Critical illness rs16940665 −7.45 2.18 × 10−8
 RP11-259G18.2 Small Intestine Terminal Ileum 17 59 EOC rs4566211 7.16 1.82 × 10−7 Critical illness rs16940665 −7.52 1.29 × 10−8
 RP11-259G18.1 Brain Hippocampus 17 65 EOC rs4566211 7.11 2.66 × 10−7 Critical illness rs16940665 −7.46 1.94 × 10−8
 CRHR1-IT1 Artery Aorta 17 93 EOC rs17631676 7.11 2.66 × 10−7 Critical illness rs16940665 −7.46 1.94 × 10−8
 LRRC37A4P Brain Amygdala 17 137 EOC rs17631676 −7.11 2.66 × 10−7 Critical illness rs16940665 7.46 1.94 × 10−8
 ABO Artery Aorta 9 595 EOC rs495828 5.60 4.92 × 10−3 Critical illness rs657152 6.68 5.70 × 10−6

Infection: reported SARS-CoV-2 infection vs. population; Hospitalization: hospitalized COVID-19 patients vs. population; Critical illness: very severe respiratory confirmed COVID-19 patients vs. population; BC: breast cancer; EOC: overall invasive epithelial ovarian cancer; TWAS: transcriptome-wide association study; GWAS: genome-wide association study; SNP: single nucleotide polymorphism; CHR: Chromosome; ID: identifier; No. SNPs: number of SNPs in the locus; Z: Z value for TWAS.