Table 3.

Physicochemical properties of different types and grades of polymers used in ASD [14,15,[21], [22], [23], [24].

Category	Chemical name	Polymer type	Molecular weight	Solubility	Hygroscopicity	Tg (or Tm °C)	Degradation temperature ( °C)
Polyvinyllactam polymers	PVP	KollidonⓇ 12 PF	2,000 – 3000	Water soluble	High	72	196
		KollidonⓇ 17 PF	7,000 – 11,000			140	217
		KollidonⓇ 25	28,000 – 34,000			153	166
		KollidonⓇ 30	44,000 – 54,000			160	171
		KollidonⓇ 90F	1,000,000 – 1500,000			177	194
	PVP/VA	KollidonⓇ VA64	MW 45,000 – 70,000	Water soluble	High	105	270
	SoluplusⓇ	SoluplusⓇ	MW 90,000 – 140,000	Water soluble	High	72	278
Cellulosic polymers	HPMC	PharmacoatⓇ 606	MW – 10,000	Water soluble	High	139	244
		Methocel™ K100LV	MW – 25,000			147, 168	259
		Methocel™ K100M	MW – 150,000			96, 173	259
	HPC	KlucelⓇ LF	MW – 95,000	Water soluble	High	0[25]	170–200
	HPMCAS	Shin-etsu AQOATⓇ MF	MW – 18,000 (3 cps)	Dissolves above pH 5.0	Low	122	204
	HPMCP	HP-55	MW – 45,600 (40 cps)	Dissolves above pH 5.0	Low	147	194
		HP-50	MW – 37,900 (55 cps)			143	199
	CAP	N/A	MW – 2534.12	Dissolves at higher pH (more than 6)	Low	175	200
Acrylate and methacrylate (co-)polymers	EudragitⓇ E PO	N/A	MW – 47,000	Dissolves in gastric fluid below pH 5.0	Low	52	250
	EudragitⓇ L 100	N/A	MW – 125,000	Dissolves above pH 6.0	Low	195	176
	EudragitⓇ S 100	N/A	MW – 125,000	Dissolves above pH 7.0	Low	173	173
	EudragitⓇ L 100–55	N/A	MW – 320,000	Dissolves above pH 5.5	Low	111	176
Other polymers	PVAP	N/A	MW 47,000–60,700	Dissolves above pH 5	Low	42.5	150
	PAA	N/A	MW 1,800–450,000	Water soluble	Low	126	200
	PEG/PEO	N/A	MW 1,000–7,000,000	Water soluble	Low	Tm=55–66	>200
	Poloxamer	N/A	MW 7,600–17,400	Water soluble	Low	Tm=52–57	>200