Figure 5.

Signaling pathway alteration with significant correlation with overall survival (OS). Survival analysis indicated that gene mutations in pathways of oxidative phosphorylation (P = 0.040) (A), apoptosis (P = 0.049) (B), interferon alpha response (P = 0.049) (C), KRAS signaling up (P = 0.049) (D), and peroxisome (P = 0.049) were significantly correlated with worse OS in R-NETs. Gene mutations in the IL6-JAK-STAT3 signaling pathway tended to associate with worse OS with a P value of 0.059. Included signaling pathways and corresponding gene sets were derived from Hallmark gene sets in the Molecular Signatures Database (Msigdb). A full-colour version of this figure can be found at https://doi.org/10.1530/ERC-22-0257.