Figure 6.

Gene alterations associated with therapy. Potentially actionable gene alterations for targeted therapy (A) and potential gene alterations with impact on the efficacy of immune checkpoint blockade (ICB) (B). Gene lists for targeted therapy and ICB were selected based on the Oncology KnowledgeBase (oncoKB) database and literature reports respectively. Clinicopathologic and genetic parameters were annotated in the top bar plots and bottom colored bars. A full-colour version of this figure can be found at https://doi.org/10.1530/ERC-22-0257.