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. 2023 Aug 11;14:1221102. doi: 10.3389/fimmu.2023.1221102

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Copyright © 2023 Qiao, Zienkiewicz, Liu and Hawiger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selective Nuclear Blockade with the NTCI Significantly Reduced Bacterial Dissemination in Blood, Lungs, Spleen, and Kidneys. Mice with induced polymicrobial peritonitis were treated for 12 hours with the NTCI without antimicrobial therapy (see Materials and Methods for details). Blood, lungs, spleen, and kidneys were collected and processed for bacterial count (n=5). Bacterial dissemination in blood and three major organs was analyzed by nonparametric t test with Mann–Whitney rank comparison. The data is presented as a mean ± SEM. ****p < 0.0001, ns, not significant.