Table 1.

List of references confirming normal learning and memory in spatial and reversal MWM task following irradiation

Radiation type	Dose	Body part irradiated	Postirradiation interval	Behavioral paradigm		Species	Reference
				Training protocol – effect on learning	Testing protocol – effect on memory
x rays	10 Gy	Hippocampus/cortex	5 wk	Visible platform MWM (days 1-2) followed by hidden platform MWM (days 3-5) – learning unaffected	Test trial on day 5 – memory unaffected	Mouse	Raber et al. (2004)
Proton particles	1.5, 3, or 4 Gy	Whole body	6.5 wk	Hidden platform MWM (days 1-3) followed by the platform relocation to a different quadrant (day 4) – learning unaffected	Test trial – memory unaffected	Rat	Shukitt-Hale et al. (2004)
γ rays (60Co)	10 Gy on 2 consecutive days	Head	4 wk	Hidden platform MWM – learning unaffected	Test trial (different mice tested at each time point): 1 week after training – memory unaffected 2 or 4 wk after training – deficient memory	Rat	Snyder et al. (2005)
x rays	3 × 5 Gy (days 1, 4, 8)	Hippocampus/cortex	∼20 d after last irradiation	Visible platform MWM (days 1-2) followed by hidden platform MWM (days 3-12); daily platform relocation (16 d) – learning unaffected	Test trial for hidden platform location (day 12 and day 26) – memory unaffected	Mouse	Saxe et al. (2006)
γ rays (137Cs)	10 Gy	Brain (cerebellum shielded)	15 wk	Nonspatial MWM (platform marked by a beacon, days 1-2), followed by spatial MWM (hidden platform, days 3-5) – learning unaffected	Test trials: day 3 after training – deficient memory days 4-5 after training – memory unaffected	Mouse	Acevedo et al. (2008)
γ rays (60Co)	3 × 5 Gy	Hippocampus/cortex	∼14 wk	Hidden platform MWM (5 d) – learning unaffected	Test trial – no between-groups comparison, but according to the graph, memory unaffected	Mouse	Clark et al. (2008)
x rays	10 Gy	Brain	∼7.5 wk	Hidden platform MWM (4 d) – learning unaffected	Test trial (same mice repeatedly tested at each time point): 24 h after training – memory unaffected 1 week after training – deficient memory 2 and 3 wk after training – memory unaffected	Mouse	Ben Abdallah et al. (2013)
Proton particles	0.5 Gy	Whole body	Before irradiation, 12 wk, repeated at 24 wk after irradiation	Cued MWM (day 1) followed by spatial MWM (day 2) and reversal MWM (day 3) Before irradiation and 12 wk after irradiation – learning unaffected 24 wk after irradiation – learning affected on block 1 of reversal MWM	Test trials on days 2 and 3 – memory unaffected	Mouse	Bellone et al. (2015)
4He	5 or 30 cGy	Whole body	52 wk	Platform relocation task: spatial MWM (days 1-4) – learning unaffected first platform relocation MWM (days 5-6) – learning unaffected second platform relocation MWM (days 7-8) – learning affected	No data for memory after spatial and 1st relocation MWM Test Trial on day 9 – memory affected	Mouse	Parihar et al. (2018)
x rays	2 Gy or 10 × 0.2 Gy	Whole body	∼8 wk	Hidden platform MWM (5 d) – learning unaffected	Test trial on day 6 – memory unaffected	Mouse	Peng et al. (2019)