TABLE 2. Summary of the most important laboratory findings of Case 2 of Crimean-Congo haemorrhagic fever, North Macedonia, July–August 2023.
| Parameters and assays | Symptom onset Day 8 after exposure to Case 1 | Day 2 after symptom onset | Day 4 after symptom onset | Day 8 after symptom onset | Day 13 after symptom onset | Reference values |
|---|---|---|---|---|---|---|
| Biochemical parameters | ||||||
| Aspartate aminotransferase (U/L) | 24 | 70 | 515 | 329 | 23 | 10–47 |
| Alanine transaminase (U/L) | 15 | 32 | 269 | 229 | 58 | 10–52 |
| Creatine kinase (U/L) | 144 | 720 | 621 | 182 | 50 | 30–170 |
| Lactate dehydrogenase (IU/mL) | 183 | 269 | 721 | 460 | 285 | 120–246 |
| C-reactive protein (mg/L) | 3 | 2 | 12 | 15 | 49 | 0–10 |
| Haematological parameters | ||||||
| Haemoglobin (g/L) | 124 | 123 | 133 | 117 | 87 | 110–160 |
| Leukocytes (109/L) | 3.3 | 2.6 | 5.0 | 5.3 | 7.5 | 4–10 |
| Platelets (109/L) | 141 | 89 | 51 | 62 | 168 | 150–400 |
| Lymphocytes (%) | 10 | 19 | 34 | 26 | 10 | 21–25 |
| Red blood cells (1012/L) | 4.6 | 4.7 | 5.0 | 4.5 | 3.3 | 3.8–5.8 |
| D-dimer (ng/mL) | 1,199 | 1,092 | 7,822 | 775 | 2,320 | 0–500 |
| Prothrombin time (s) | 13.2 | 11.1 | 11.9 | 10.3 | 15.3 | 9.8–14.2 |
| Thrombin time (s) | 19.9 | 21.7 | 45.8 | 31.9 | 31 | 16.1–24.1 |
| Microbiological analyses | ||||||
| CCHFV RNA | Positive | NA | NA | NA | NA | Not applicable |
CCHFV: Crimean-Congo haemorrhagic fever virus; NA: not analysed; U: unit.