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Potential signaling routes for LCN2. LCN2 has affinity for five putative receptors (NGALR, LRP2, MC4R, MC1R, and MC3R) and additional binding partners (e.g., MMP-9, MMP-2, HGF). Binding of LCN2 to these biomolecules can modulate activity of respective proteins/receptors or modulate signaling cascades triggered. In addition to these receptors, LCN2 was recently found to bind to LRP6 in mouse embryonic fibroblasts (49).
