Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 11;14:1229885. doi: 10.3389/fimmu.2023.1229885

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Schröder, Gasterich, Weiskirchen and Weiskirchen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Immunohistochemical staining of MC4R and LRP2/megalin. (A) Tissue sections from (a) kidney, (b) colon, (c) bone marrow and (d) brain were stained with a validated antibody (HPA016719) specific for MC4R. Please note that the antibody stained tubular cells in the kidney, hematopoietic cells in the bone marrow, glandular cells in the colon, while only showing low staining in some neuronal cells in the brain. (B) Tissue sections from (a, b) kidney and (c, d) parathyroid gland were stained with two (validated) polyclonal rabbit antibodies (i.e., HPA005980 and HPA064792) directed against human LRP2. Please note that both antibodies stained similar structures in kidney, while the staining was markedly different in two sections of the parathyroid gland that were taken from the same patient. All images were taken from the Human Protein Atlas (91) database [https://www.proteinatlas.org/ 92]. The images depicted in (A) can be found at: (a) https://www.proteinatlas.org/ENSG00000166603-MC4R/tissue/kidney#img, (b) https://www.proteinatlas.org/ENSG00000166603-MC4R/tissue/colon#img, (c), https://www.proteinatlas.org/ENSG00000166603-MC4R/tissue/bone+marrow#img, and (d) https://www.proteinatlas.org/ENSG00000166603-MC4R/tissue/cerebral+cortex#img. The images depicted in (B) can be found at: (a, b) https://www.proteinatlas.org/ENSG00000081479-LRP2/tissue/kidney#img and (c, d) https://www.proteinatlas.org/ENSG00000081479-LRP2/tissue/parathyroid+gland#img.