Table 1.
Characteristics at index date of incident OAD users not prescribed a lipid lowering medication in the baseline period
| Characteristic | Metformin (n = 3435) | Sulfonylurea (n = 3237) | Metformin + sulfonylurea (n = 629) |
|---|---|---|---|
| Age, median (IQR) | 60 (53, 69) | 65 (55, 76) | 59 (52, 68) |
| Male (%) | 94 | 97 | 95 |
| Race (%) | |||
| White | 74 | 72 | 66 |
| Black | 14 | 20 | 20 |
| Other/unknown | 12 | 8 | 14 |
| Use of medications that affect lipids (%) | |||
| Corticosteroids | 7.0 | 7.3 | 4.6 |
| Thyroid replacement | 5.6 | 6.1 | 4.0 |
| Anticonvulsants | 1.5 | 2.0 | 1.7 |
| Thiazide diuretics | 30.7 | 26.1 | 18.6 |
| HbA1c available (%) | 71.3 | 65.5 | 61.4 |
| HbA1c, median (IQR) | 7.2 (6.5, 8.0) | 7.3 (6.5, 8.4) | 8.2 (7.0, 10.5) |
| BMI available (%) | 94.2 | 92.5 | 90.0 |
| BMI, median (IQR) | 32.3 (28.3, 36.6) | 29.7 (26.3, 33.8) | 30.7 (27.4, 35.1) |
| History of CVD* (%) | 9.6 | 16.4 | 10.8 |
| Total cholesterol available (%) | 70.6 | 63.8 | 56.6 |
| Total cholesterol, median (IQR) | 186 (163, 211) | 185 (160, 210) | 189.5 (160.8, 220) |
| LDL available (%) | 60.3 | 54.9 | 45.6 |
| LDL, median (IQR) | 109 (89, 129) | 107 (86, 129) | 109 (85.9, 132.5) |
| HDL available (%) | 69.4 | 62.2 | 53.4 |
| HDL, median (IQR) | 36 (31, 44) | 36 (31, 44) | 37 (31, 44) |
| Triglycerides available (%) | 69.6 | 62.5 | 53.7 |
| Triglycerides, median (IQR) | 176 (121, 253) | 174 (117, 252) | 177.5 (118.2, 279) |
| Number of outpatient medications, median (IQR) | 3 (1, 6) | 3 (1, 6) | 1 (0, 3) |
| Number of outpatient visits, median (IQR) | 4 (2, 7) | 4 (2, 7) | 3 (2, 5) |
| Hospitalized (%) | 8.0 | 14.0 | 8.7 |
*
Defined as one inpatient or two outpatient codes for myocardial infarction; angina or coronary artery disease or prescription for a long acting nitrate; transient ischemic attack; stroke/cerebrovascular disease; carotid artery disease; or peripheral vascular disease.