Table 6.
Plant-derived bioactive compounds with neuroprotective effects in AD patients.
| Neuroprotective-Based Activity | |||||||
|---|---|---|---|---|---|---|---|
| Plant | Bioactive Compound | NrF Activation | Antioxidant | Antiapoptotic | OS Reduction | AChE Decrease | Refs. |
|
Citrus plants (dose 50 µM/cells culture) |
Naringenin, quercetin, sinensetin | X | X | [71,72,73] | |||
|
Orthosiphon stamineus (dose 10/20/40 µM/SH-SY5Y cell) |
Sinensetin | X | X | [72] | |||
|
Cammelia sinensis (dose 12.5–25 mg/kg mice) |
Quercetin | X | X | X | [74] | ||
|
Rhodiola rosea (dose 1 mg/kg mice) |
Rosidin | X | X | X | [74] | ||
|
Glutinous rehmannia Dracocephalum moldavica (dose 80 mg/kg mice) |
Rehrmannioside A, tilianin | X | X | [75,76] | |||
|
Cammelia sinensis (dose 10 mg/kg mice) |
Kaempferol, | X | X | [77] | |||
|
Morinda lucida (dose 5 mg/kg mice) |
Morin, marinoid J | X | X | [78,79] | |||
|
Curcuma longa (dose 1–15 µM/SH-Sy5Y cells) |
Curcumin | X | X | [81] | |||
| Elaeagnus glabra f. oxyphylla | Procyanindin | [84] | |||||
|
Glycine max (dose 40–160 µM/kg mice) |
Coumestrol | X | X | [85] | |||
|
Aralia nudicaulis (dose 2.5 µM/mouse neuroblastoma neuro-2a) |
Ginsenoside | X | X | [87] | |||
|
Gochnatia polymorpha (dose 1–1000 mouse neuroblastoma neuro-2a)/NSC-34 cells) |
Bisalol | X | X | [88] | |||