TABLE 1.
Mortality in chickens infected with E. coli K1+ with and without simultaneous administration of phage
| Chickens | Intramuscular inoculation (106 CFU)
|
Intracranial inoculation (103 CFU)
|
||
|---|---|---|---|---|
| Phage dose (PFU)a | Mortalityb | Phage dose (PFU)c | Mortalityb | |
| 3 weeks old | 106 | 0/5 | 108 | 0/5* |
| 104 | 0/5 | —d | 3/5 | |
| 102 | 2/5* | |||
| — | 5/5 | |||
| Newly hatched | 106 | 0/10 | 108 | 2/10*** |
| — | 10/10 | 106 | 6/10** | |
| — | 10/10 | |||
a
E. coli was administered into one leg, and phage was administered into the other leg.
b
Number of chickens dead out of the number infected. Statistically significant differences from the corresponding values for chickens not given phage are indicated as follows: *, P ≅ 0.03; **, P = 0.02; ***, P < 0.01.
c
Phage was given intramuscularly.
d
—, no phage was administered.