TABLE 2.
Kinetics of infection in 3-week-old chickens simultaneously administered E. coli K1+ intracranially (103 CFU) and bacteriophage intramuscularly (108 PFU)
| Time (h) postinfection |
E. coli count (log10 CFU/g) in:
|
Phage count (log10 PFU/g) in:
|
||||
|---|---|---|---|---|---|---|
| Spleen | Blood | Brain | Spleen | Blood | Brain | |
| E. coli only | ||||||
| 0 | <2a | <2 | <2 | <2 | <2 | <2 |
| 3 | 4.1 | 2.0 | 4.2 | <2 | <2 | <2 |
| 6 | 4.7 | 3.7 | 6.4 | <2 | <2 | <2 |
| 12 | 5.4 | 5.2 | 8.2 | <2 | <2 | <2 |
| 24 | —b | — | — | — | — | — |
| E. coli and phage | ||||||
| 0 | <2 | <2 | 2.6 | <2 | 3.1 | <2 |
| 3 | 2.8 | 1.6 | 4.2 | 7.2 | 6.5 | 3.8 |
| 6 | 3.9 | 2.1 | 5.5 | 6.6 | 6.4 | 7.3 |
| 12 | 3.0 | <2 | 3.3 | 6.7 | 6.6 | 7.6 |
| 24 | <2 | <2 | 4.3 | 7.1 | 4.3 | 7.2 |
| 48 | <2 | <2 | 1.7 | 6.9 | 1.6 | 4.2 |
| 120 | <2 | <2 | 1.2 | 5.9 | <2 | <2 |
<2 = <100.
—, all birds dead.