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Dose–response curves of Nitroxoline against N. fowleri and murine macrophages J774A.1 (ATCC® TIB-67). The amoebicidal activity of Nitroxoline against ATCC® 30808™ (A) and ATCC® 30215™ (B) strains of N. fowleri after 48 h is shown. In addition, the cytotoxicity effect against murine macrophages (C) was measured after 24 h of incubation with the drug. Activity and cytotoxicity experiments were performed using three independent assays, as illustrated in the graphical legends.
