Table 4.
Main studies on presepsin accuracy for diagnosis of neonatal sepsis.
| Reference | Population | EOS or LOS | Cut-off Value | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|
| Poggi 2015 [192] |
Preterm (≤32 wks of GA): 19 LOS vs. 21 controls |
LOS | 885 ng/L | 94% | 100% | 100% | 95% |
| Mussap 2015 [193] |
Mixed, term and preterm: group A (25 bacterial sepsis), group B (15 SIRS, with no localizing source of bacterial infection), group C (25 non-infected) |
EOS and LOS | 548 ng/L | 100% | 81.2% | ND | ND |
| 600 ng/L | 97.5% | 100% | |||||
| Stojewska 2015 [194] | Mixed, term and preterm: 41 septics, 37 with severe local infections without bacteremia, 16 without infections, but with clinical symptoms suggesting infection and perinatal risk factors and 30 control |
EOS and LOS | 1066 pg/mL | 63.4% | 89.2% | ND | ND |
| Topcuoglu 2015 [195] |
Preterm (≤32 wks of GA): 42 LOS vs. 40 controls |
LOS | 800.5 pg/mL | 67% | 100% | 100% | 74% |
| Abdel Motalib 2015 [196] |
Mixed, term and preterm: 28 cases vs. 34 controls |
EOS | 672 pg/mL | 97% | 98% | 96% | 92% |
| Osman 2015 [197] |
Full term neonate: 40 cases vs. 15 controls |
EOS and LOS | 875 pg/mL | 95.7% | 87.5% | ND | ND |
| Xiao 2017 [198] |
Mixed, term and preterm: 42 hematosepsis vs. 54 nonhematosepsis vs. 44 non-infectious vs. 53 healthy controls |
EOS and LOS | 304.5 ng/mL | 95.2% | 84.9% | ND | ND |
| Miyosawa 2018 [199] |
Preterm: 13 cases vs. 18 preterm controls vs. 35 term controls |
EOS | 795 pg/mL | 85% | 89% | 85% | 89% |
| Gad 2020 [200] |
Full-term: 31 cases vs. 20 controls |
EOS | 480 ng/L | 96.8% | 95% | 96.8% | 95% |
| 1400 ng/L | 100% | 88.5% | 55.6% | 94.7% | |||
| Pietrasanta 2021 [201] |
Mixed, term and preterm: 58 “infection” vs. 77 septic vs. 24 septic shock |
EOS | Overall: 987.5 pg/mL |
72% | 87% | 57% | 93% |
| Infection: 687.5 pg/mL |
81% | 62% | 15% | 98% | |||
| Sepsis: 1013 pg/mL |
84% | 92% | 45% | 98% | |||
| Septic shock: 971.5 pg/mL |
92% | 86% | 18% | 100% |
Table Legend: EOS (early onset sepsis); LOS (late onset sepsis); PPV (positive predictive value); NPV (negative predictive value); wks (weeks); GA (gestational age); SIRS (systemic inflammatory response syndrome); ND (not declared).