Figure 4.

EGCG-associated gene signatures are transferred to kidney datasets with other antioxidant compounds. (A) Venn diagram comparison of the human skin and T-cell up- and downregulated EGCG gene signatures to dataset GSE198890 of HEK cells treated with VT01454 shows only 1+1 genes overlapping. (B) In dataset GSE159656 of Galoderma lucidum-treated mouse kidney cells, there is more overlap of the indicated six genes in the downregulated EGCG signature and two genes in the upregulated EGCG signature. (C) The six EGCG-downregulated genes overlapping can be further characterised by the overrepresented renal impairment processes found by the R package EnrichR; however, they are only associated with single genes: SLC12A1 or LOX.