Table 1.
Features of Salmonella Isangi (n = 15) displaying point mutation in gyrA and parC genes, conferring resistance to ciprofloxacin and nalidixic acid.
| Isolate ID | Location | Year of Isolation | Resistome | Gene | Mutation | Predicted Phenotype |
|---|---|---|---|---|---|---|
| ERR4399363 | South Africa | 2001 | aac(3)-IIa, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, ARR-3, blaOXA-10, blaSCO-1, blaTEM-63, cmlA1, dfrA23, floR, gyrA (D87N), qacE, sul1, sul2, tet(A) | gyrA (D87N) | GAC→AAC (D→N) | ciprofloxacin I/R, nalidixic acid |
| ERR4400265 | South Africa | 2001 | aac(3)-IIa, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, ARR-3, blaOXA-10, blaSCO-1, blaTEM-63, cmlA1, dfrA23, floR, gyrA (D87N), qacE, sul1, sul2, tet(A) | gyrA (D87N) | GAC→AAC (D→N) | ciprofloxacin I/R, nalidixic acid |
| ERR4400834 | Tawain | 2007 | gyrA (S83F) | TCC→TTC (S→F) | ciprofloxacin I/R, nalidixic acid | |
| ERR4400884 | South Africa | 2001 | aac(3)-IIa, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, ARR-3, blaOXA-10, blaSCO-1, blaTEM-63, cmlA1, dfrA23, floR, gyrA (D87N), qacE, sul1, sul2, tet(A) | gyrA (D87N) | GAC→AAC (D→N) | ciprofloxacin I/R, nalidixic acid |
| ERR4401297 | South Africa | 2001 | aac(3)-IIa, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, ARR-3, blaOXA-10, blaSCO-1, blaTEM-63, cmlA1, dfrA23, floR, gyrA (D87N), qacE, sul1, sul2, tet(A) | gyrA (D87N) | GAC→AAC (D→N) | ciprofloxacin I/R, nalidixic acid |
| ERR4401298 | South Africa | 2001 | aac(3)-IIa, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, ARR-3, blaOXA-10, blaSCO-1, blaTEM-63, cmlA1, dfrA23, floR, gyrA (D87N), qacE, sul1, sul2, tet(A) | gyrA (D87N) | GAC→AAC (D→N) | ciprofloxacin I/R, nalidixic acid |
| ERR4401299 | South Africa | 2001 | aac(3)-IIa, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, ARR-3, blaOXA-10, blaSCO-1, blaTEM-63, cmlA1, dfrA23, floR, gyrA (D87N), qacE, sul1, sul2, tet(A) | gyrA (D87N) | GAC→AAC (D→N) | ciprofloxacin I/R, nalidixic acid |
| ERR4401598 | South Africa | 2001 | aac(3)-IIa, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, ARR-3, blaOXA-10, blaSCO-1, blaTEM-63, cmlA1, dfrA23, floR, gyrA (D87N), qacE, sul1, sul2, tet(A) | gyrA (D87N) | GAC→AAC (D→N) | ciprofloxacin I/R, nalidixic acid |
| ERR6806075 | South Africa | 2020 | aac(3)-IIa, aph(3″)-Ib, aph(6)-Id, blaCTX-M-15, blaTEM-1B, catB3, gyrB (S464F), sul2 | gyrB (S464F) | TCT→TTC (S→F) | ciprofloxacin I/R |
| SRR1106479 | Unknown | gyrA (S83F) | TCC→TTC (S→F) | ciprofloxacin I/R, nalidixic acid | ||
| SRR1264936 | India | 2011 | parC (T57S) | parC (T57S) | ACC→AGC (T→S) | None |
| SRR13633613 | United Kingdom | 2021 | parC (T57S) | parC (T57S) | ACC→AGC (T→S) | None |
| SRR13633625 | United Kingdom | 2021 | parC (T57S) | parC (T57S) | ACC→AGC (T→S) | None |
| SRR13633627 | United Kingdom | 2021 | parC (T57S) | parC (T57S) | ACC→AGC (T→S) | None |
| SRR13633629 | United Kingdom | 2021 | parC (T57S) | parC (T57S) | ACC→AGC (T→S) | None |
| SRR13645903 | United Kingdom | 2021 | parC (T57S) | parC (T57S) | ACC→AGC (T→S) | None |
| SRR3002515 | United States | 2009 | parC (T57S) | parC (T57S) | ACC→AGC (T→S) | None |