Table 2.
Association of polymorphisms homocysteine metabolism genes with cancer risk. (odds ratio is indicated as OR).
| Genes | Polymorphisms | Cancer Types | Significant Association (OR) | References |
|---|---|---|---|---|
| MTHFR | 677C-> T | Breast Cancer | Positive Association (1.19) | [22] |
| Ovarian Cancer | No association (1.03) | [22] | ||
| Esophageal Squamous Cell Carcinoma | Positive Association (1.47) | [96] | ||
| Acute Lymphocytic Leukemia | Negative Association (0.99) | [21] | ||
| Prostate Cancer | Negative association (0.78) | [23] | ||
| Colorectal Adenomas | Negative association (0.76) | [97] | ||
| Late-stage colorectal tumorigenesis | Positive Association (1.32) | [29] | ||
| Endometrial Cancer | No association (1.10) | [98] | ||
| 1298A->C | Prostate Cancer | Negative Association (0.58) | [99] | |
| Acute Lymphocytic Leukemia | Negative Association (0.33) | [21] | ||
| Acute Myeloid Leukemia | No association (1.00) | [88] | ||
| Endometrial Cancer | No association (1.00) | [98] | ||
| MTRR | 66A->G | Acute Myeloid Leukemia | Positive association for Asian population (1.40) | [100] |
| Head and Neck Cancer | Positive Association (1.24) | [101] | ||
| Colorectal Cancer | Positive Association (2.77, 1.15) | [87,102] | ||
| Gastric Cancer | Positive Association (1.39) | [103] | ||
| Breast Cancer | Positive Association (4.45) | [104] | ||
| MTR | b2756A->G | Colorectal Cancer | Positive Association (2.04) | [28] |
| Primary Liver Cancer | No association (1.00) | [105] | ||
| Breast Cancer | No association (1.00) | [106] | ||
| Glioblastoma Multiforme | No association (1.00) | [107] | ||
| Upper Gastrointestinal Tract cancer | No association (1.00) | [108] | ||
| Digestive System Cancer | No association (1.00) | [109] | ||
| MTHFD1 | 1958G->A | Gastric Cancer | Positive Association (2.05) | [110] |
| G1958A | Colon Cancer | Negative Association (0.89) | [111] | |
| BHMT | 742G->A | Head and Neck Squamous Cell Carcinoma | Positive Association (1.34) | [112] |
| Breast Cancer | No association (0.98) | [113] | ||
| Cervical Cancer | Negative Association (0.433) | [114] | ||
| Ovarian Cancer | No association (1.00) | [115] | ||
| Colorectal Adenoma | Positive Association (1.09) | [116] | ||
| TCN 2 | 776G>C | Glioblastoma Multiforme | No association (1.00) | [107] |
| Primary Central Nervous System Lymphoma | No association (1.00) | [117] | ||
| TYMS | TS 3′-UTR | Esophageal and Stomach Cancer | No association (1.00) | [118] |