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. 2023 Aug 21;10(8):987. doi: 10.3390/bioengineering10080987

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Anti-aging potential of PRP. DNA damage leads to cellular senescence and inflammation, which, with advancing age, accumulates SASP and inflammaging factors, respectively. Both contribute towards aging and age-related changes, specifically towards age-related diseases (ARDs) that impact the quality of life (QOL). PRP intervention has been shown to alleviate pain and disease progression in OA and reduce inflammatory markers and senescent cells (indicated in solid green lines), all of which are either precursors of aging or the effect of age-related changes. Investigations focused on the anti-aging property of PRP for age-related diseases (excluding those aimed at cosmetic applications) are yet to be explored and are indicated in the green dotted line.