Table 1.
Functional Enrichment Analysis of the DEMs.
| 3D MSCs | 3D MSC EXOs | γ-MSCs | γ-MSCs EXOs | ||||
|---|---|---|---|---|---|---|---|
| GO Terms | miRNAs | GO Terms | miRNAs | GO Terms | miRNAs | GO Terms | miRNAs |
| response to hypoxia |
miR-100-5p; miR-101-3p; miR-132-3p; miR-144-3p; miR-148a-3p; miR-181c-5p; miR-186-5p; miR-199a-5p; miR-212-3p; miR-23b-3p; miR-296-3p; miR-429 | blood vessel development | let-7a-5p; let-7c-5p; miR-132-3p; miR-200c-3p; miR-212-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-34a-5p | immune system process |
miR-492 | apoptotic signaling pathway | miR-133b; miR-135a-5p; miR-141-3p; miR-486-3p; miR-139-5p; miR-182-5p; miR-133a-3p; miR-429; miR-448; miR-205-5p; miR-198; let-7b-5p; miR-125b-5p |
| response to growth factor | miR-101-3p; miR-124-3p; miR-132-3p; miR-1-3p; miR-144-3p; miR-148a-3p; miR-181c-5p; miR-183-5p; miR-186-5p; miR-194-5p; miR-199a-5p; miR-23b-3p; miR-429; miR-497-5p | hepatic Immune response |
let-7a-5p; let-7c-5p | positive regulation of programmed cell death |
miR-133b | morphogenesis of a branching epithelium | miR-33b-5p; miR-133b; miR-429; miR-448; miR-205-5p; miR-198; miR-125b-5p |
| cellular response to cytokine stimulus | miR-101-3p; miR-124-3p; miR-132-3p; miR-1-3p; miR-144-3p; miR-148a-3p; miR-183-5p; miR-186-5p; miR-194-5p; miR-199a-5p; miR-212-3p; miR-429; miR-892b | tube morphogenesis | let-7a-5p; miR-130b-3p; miR-132-3p; miR-200c-3p; miR-212-3p; miR-21-5p; miR-22-3p; miR-33b-5p; miR-34a-5p | intrinsic apoptotic signaling pathway |
miR-188-3p | chronic inflammatory response | miR-452-5p; miR-125b-5p |
| sprouting angiogenesis |
miR-101-3p; miR-124-3p; miR-132-3p; miR-144-3p | vasculature development | let-7a-5p; let-7c-5p; miR-200c-3p; miR-212-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-34a-5p | lymphocyte activation | miR-139-5p | positive regulation of response to oxidative stress | miR-452-5p; miR-125b-5p |
| apoptotic process | miR-100-5p; miR-101-3p; miR-124-3p; miR-1-3p; miR-148a-3p; miR-149-5p; miR-181c-5p; miR-183-5p; miR-193b-3p; miR-199a-5p; miR-212-3p; miR-23b-3p; miR-296-3p; miR-429; miR-497-5p; miR-518c-3p | apoptotic signaling pathway |
let-7b-5p; miR-106b-5p; miR-15b-5p; miR-200c-3p; miR-212-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-34a-5p; miR-744-5p | cell differentiation |
miR-1249-3p; miR-125a-5p; miR-125b-5p; miR-133a-3p; miR-133b; miR-135b-5p; miR-145-5p; miR-19a-3p; miR-204-5p; miR-20a-5p; miR-210-3p; miR-224-5p; miR-27b-3p; miR-331-3p; miR-335-5p; miR-33a-5p; miR-378a-3p; miR-495-3p; miR-518c-3p; miR-9-5p | epithelial to mesenchymal transition | miR-182-5p; miR-429; miR-205-5p; miR-452-5p |
| negative regulation of cell cycle | miR-101-3p; miR-124-3p; miR-144-3p; miR-148a-3p; miR-149-5p; miR-183-5p; miR-186-5p; miR-193b-3p; miR-212-3p; miR-219a-5p; miR-23b-3p; miR-429; miR-615-3p | tube development | miR-130b-3p; miR-132-3p; miR-200c-3p; miR-212-3p; miR-21-5p; miR-22-3p; miR-33b-5p; miR-34a-5p | regulation of phosphatidylinositol 3-kinase signaling | miR-125a-5p; miR-125b-5p; miR-133b; miR-145-5p | activation of MAPK activity | miR-205-5p; miR-125b-5p |
| activation of NF-kappaB-inducing kinase activity |
miR-875-5p; miR-892b | positive regulation of immune system process | miR-132-3p; miR-200c-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-33b-5p; miR-34a-5p; miR-34b-5p | cellular response to growth factor stimulus |
miR-125a-5p; miR-125b-5p; miR-133a-3p; miR-133b; miR-135b-5p; miR-145-5p; miR-15a-5p; miR-194-5p; miR-195-5p; miR-19a-3p; miR-204-5p; miR-23b-3p; miR-25-3p; miR-27b-3p; miR-378a-3p; miR-424-5p; miR-495-3p; miR-9-5p | T-helper cell differentiation | miR-33b-5p; miR-9-5p |
| positive regulation of T cell cytokine production | miR-875-5p; miR-892b | regulation of fibroblast proliferation | miR-130b-3p; miR-132-3p; miR-200c-3p; miR-212-3p; miR-21-5p; miR-22-3p; miR-34a-5p; miR-34b-5p | positive regulation of cell growth | miR-125a-5p; miR-125b-5p; miR-133a-3p; miR-133b; miR-145-5p; miR-224-5p | T cell differentiation involved in immune response | miR-33b-5p; miR-9-5p |
| tube development | miR-101-3p; miR-124-3p; miR-132-3p; miR-1-3p; miR-144-3p; miR-148a-3p; miR-199a-5p; miR-212-3p; miR-219a-5p; miR-335-5p; miR-429 | activation of immune response | miR-132-3p; miR-15b-5p; miR-200c-3p; miR-21-5p | response to wounding | miR-125a-5p; miR-133a-3p; miR-133b; miR-145-5p; miR-194-5p; miR-195-5p; miR-19a-3p; miR-204-5p; miR-224-5p; miR-494-3p; miR-9-5p | coronary vasculature development | miR-9-5p; miR-503-5p; let-7c-5p |
| regulation of cell migration involved in sprouting angiogenesis | miR-101-3p; miR-124-3p; miR-132-3p; miR-1-3p; miR-144-3p; miR-497-5p | activation of innate immune response | miR-130b-3p; miR-132-3p; miR-200c-3p; miR-21-5p | anatomical structure morphogenesis | miR-125a-5p; miR-125b-5p; miR-133a-3p; miR-133b; miR-135b-5p; miR-145-5p; miR-195-5p; miR-19a-3p; miR-204-5p; miR-210-3p; miR-224-5p; miR-27b-3p; miR-331-3p; miR-335-5p; miR-33a-5p; miR-424-5p; miR-452-5p; miR-518c-3p; miR-9-5p | anatomical structure morphogenesis | miR-33b-5p; miR-9-5p; miR-1-3p; miR-133b; miR-135a-5p; miR-141-3p; miR-582-5p; miR-182-5p; miR-183-5p; miR-133a-3p; miR-429; miR-448; miR-205-5p; miR-452-5p; miR-125b-5p |
| programmed cell death | miR-100-5p; miR-101-3p; miR-124-3p; miR-1-3p; miR-148a-3p; miR-149-5p; miR-181c-5p; miR-183-5p; miR-193b-3p; miR-199a-5p; miR-212-3p; miR-296-3p; miR-429; miR-497-5p; miR-518c-3p | innate immune response-activating signal transduction | miR-130b-3p; miR-132-3p; miR-200c-3p; miR-21-5p | tube morphogenesis |
miR-125a-5p; miR-125b-5p; miR-133a-3p; miR-133b; miR-135b-5p; miR-145-5p; miR-19a-3p; miR-204-5p; miR-210-3p; miR-224-5p; miR-27b-3p; miR-335-5p; miR-452-5p; miR-9-5p | cytokine-mediated signaling pathway | miR-9-5p; miR-1-3p; miR-98-5p; miR-133b; miR-135a-5p; miR-139-5p; miR-183-5p; miR-133a-3p; miR-429; miR-448; miR-205-5p; miR-452-5p; miR-125b-5p |
| tissue morphogenesis |
miR-101-3p; miR-124-3p; miR-1-3p; miR-144-3p; miR-148a-3p; miR-186-5p; miR-199a-5p; miR-219a-5p; miR-410-3p; miR-429 | regulation of innate immune response | miR-130b-3p; miR-132-3p; miR-200c-3p; miR-21-5p | cell activation involved in immune response | miR-125b-5p; miR-133a-3p; miR-133b | B cell homeostasis | miR-429; miR-125b-5p |
| negative regulation of cell motility | miR-101-3p; miR-124-3p; miR-1-3p; miR-144-3p; miR-148a-3p; miR-429 | response to growth factor | let-7c-5p; miR-130b-3p; miR-132-3p; miR-15b-5p; miR-200c-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-33b-5p; miR-34a-5p; miR-34b-5p; miR-424-5p; miR-744-5p | cell differentiation involved in embryonic placenta development | miR-125a-5p; miR-125b-5p; miR-133b | lymphocyte homeostasis | miR-429; miR-125b-5p |
| negative regulation of cellular component movement | miR-101-3p; miR-124-3p; miR-1-3p; miR-144-3p; miR-148a-3p; miR-429 | response to cytokine | miR-132-3p; miR-15b-5p; miR-200c-3p; miR-212-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-33b-5p; miR-34a-5p; miR-34b-5p; miR-744-5p | leukocyte activation involved in immune response | miR-125b-5p; miR-133a-3p; miR-133b | monocyte differentiation | miR-429; miR-205-5p |
| positive regulation of epithelial cell migration |
miR-101-3p; miR-124-3p; miR-132-3p; miR-1-3p; miR-144-3p; miR-149-5p; miR-199a-5p; miR-429 | insulin receptor signaling pathway | miR-15b-5p; miR-200c-3p; miR-21-5p; miR-22-3p | leukocyte mediated immunity | miR-10a-5p; miR-133a-3p; miR-133b | chemokine C-C motif ligand 2 secretion | miR-9-5p; miR-1-3p |
| positive regulation of cell migration involved in sprouting angiogenesis | miR-101-3p; miR-124-3p; miR-132-3p; miR-144-3p; miR-199a-5p | regulation of endothelial cell migration | miR-132-3p; miR-200c-3p; miR-21-5p; miR-22-3p | cytokine-mediated signaling pathway | miR-125a-5p; miR-125b-5p; miR-133a-3p; miR-133b; miR-135b-5p; miR-145-5p; miR-15a-5p; miR-204-5p; miR-224-5p; miR-23b-3p; miR-378a-3p; miR-452-5p; miR-9-5p | coronary vasculature morphogenesis | miR-9-5p; miR-1-3p |
| cellular response to fibroblast growth factor stimulus | miR-124-3p; miR-132-3p; miR-1-3p | negative regulation of apoptotic process | let-7a-5p; let-7c-5p; miR-15b-5p; miR-200c-3p; miR-212-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-30e-3p; miR-33b-5p; miR-34a-5p; miR-543; miR-744-5p | regulation of apoptotic process | miR-106b-5p; miR-125a-5p; miR-125b-5p; miR-133a-3p; miR-133b; miR-145-5p; miR-15a-5p; miR-195-5p; miR-19a-3p; miR-204-5p; miR-20a-5p; miR-210-3p; miR-27b-3p; miR-331-3p; miR-33a-5p; miR-378a-3p; miR-424-5p; miR-495-3p; miR-518c-3p; miR-9-5p | developmental cell growth | miR-9-5p; miR-1-3p |
| anatomical structure formation involved in morphogenesis | miR-101-3p; miR-124-3p; miR-1-3p; miR-144-3p; miR-148a-3p; miR-199a-5p; miR-29b-1-5p; miR-335-5p; miR-429 | cellular response to cytokine stimulus | miR-132-3p; miR-15b-5p; miR-200c-3p; miR-212-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-33b-5p; miR-34a-5p; miR-744-5p | positive regulation of cell differentiation | miR-125a-5p; miR-125b-5p; miR-133b; miR-135b-5p; miR-145-5p; miR-19a-3p; miR-204-5p; miR-224-5p; miR-23b-3p; miR-329-3p; miR-518c-3p; miR-9-5p | fibroblast migration | miR-33b-5p; miR-1-3p |
| mesenchyme development | miR-101-3p; miR-124-3p; miR-144-3p; miR-148a-3p; miR-199a-5p; miR-219a-5p; miR-29b-1-5p; miR-410-3p; miR-429 | cellular response to oxygen levels |
miR-106b-5p; miR-132-3p; miR-200c-3p; miR-212-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-33b-5p; miR-34a-5p; miR-543 | positive regulation of endothelial cell proliferation | miR-125a-5p; miR-133b; miR-145-5p | positive regulation of MAP kinase activity | miR-503-5p; miR-429; miR-205-5p; miR-125b-5p |
| fibroblast migration | miR-101-3p; miR-1-3p; miR-144-3p | lymphocyte activation | miR-15b-5p; miR-200c-3p; miR-214-3p; miR-21-5p; miR-22-3p; miR-34a-5p; miR-34b-5p | positive regulation of vascular endothelial cell proliferation | miR-125a-5p; miR-133b; miR-145-5p | leukocyte differentiation | miR-9-5p; miR-133b; miR-182-5p; miR-133a-3p; miR-429; miR-205-5p; miR-125b-5p |