Figure 3.

Receiver operating characteristic (ROC) curves of indexed creatinine clearance associated with overdosed (A) and underdosed (B) β-lactam antibiotics (blue lines). The optimal cutoff values for ß-lactam overdosing and underdosing calculated from these ROC curves were iCL_CR ≤ 43 mL/min/m² (sensitivity 83.3% and specificity 77.3%) and iCL_CR ≥ 79 mL/min/m² (sensitivity 56.9% and specificity 74.4%), respectively (green dots and dotted lines). Gray lines: 95% confidence interval (CI) bounds. Red line: identity line. AUC, area under curve.