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. 2023 Aug 15;12(8):1616. doi: 10.3390/antiox12081616

Figure 1.

Figure 1

Figure 1

The effect of under-expression of mitochondrial dPrxs in the fat body (A) and in the midgut (B) on the life span of flies. dPrx3 was under-expressed in the dprx5 null background using the inducible S106-pSwitch-GAL4 (fat body) and NP1-GAL4 (midgut) drivers. For comparison, dPrx3 was under-expressed globally with the Da-Gal4 driver (DM, red dotted lines). (A) To activate the gene switch-inducible driver, S106 DM flies were fed food containing RU486 (experimental, fat-body DM), while control flies were fed food with ethanol (control), as described in Section 2. (B) DM—Double mutant under-expressing dPrx3 globally with Da-GAL4 driver; NP1 DM—double mutant under-expressing dPrx3 in the midgut; Control—NP1-GAL4 driver. Approximately 100–125 flies were used for each fly line in the experiment. Shown are representative data of two independent biological experiments, and similar results were obtained in a replicate experiment. A summary of the data is presented in Table 2. The fly lines and genotypes of the flies are described in detail in Table 1.