Table 1.

Main markers and functions of relevant CAF subtypes in pancreatic cancer. This table summarizes the main markers and functions of three different CAF subtypes that are relevant in pancreatic cancer: myofibrotic CAFs (myCAFs), inflammatory CAFs (iCAFs), and antigen-presenting CAFs (apCAFs).

CAF Subtypes	Markers	Functions	References
myCAFs	αSMA, Col1a1, TAGLN, MYL9, TPM1, TPM2, MMP11, POSTN	ECM remodeling, Tumor invasion, proliferation, and metastasis	[10,14,23,29,30]
iCAFs	IL-6, IL-8, CXCL1, CXCL2, CXCL12, PDGFRα, CFD, CCL2,	Immune suppression, Chemoresistance	[11,14,15,17,23]
apCAFs	MHC II, CD74	Antigen presentation, Immune modulation	[15,17,22,23]

αSMA; alpha Smooth Muscle Actin, CCL2; C-C motif chemokine ligand 2, CD74; Cluster of Differentiation 74, CFD; Complement Factor D, Col1a1; Collagen type 1 alpha chain 1, CXCL1; C-X-C motif chemokine ligand, CXCL2; C-X-C motif chemokine ligand 2, CXCL12; C-X-C motif chemokine ligand 12, IL-6; Interleukin-6, IL-8; Interleukin-8, MHC II; Major histocompatibility complex II, MMP11; Matrix metalloproteinase 11, MYL9; Myosin light chain 9, PDGFRα; Platelet-derived growth factor receptor alpha, POSTN; Periostin, TAGLN; Transgelin, TPM1; Tropomyosin 1, TPM2; Tropomyosin 2.