TABLE 4.
Neutralizing antibody seroconversion patterns for rotavirus VP4 and VP7 proteins in children with serologically defined primary rotavirus infections
| Serotypes of infecting virus (no. of samples) | No. of children showing the indicated NtAb seroconversion patterns to rotavirus surface protein indicated (GMT)a
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| VP7
|
VP4
|
|||||||||
| G1 | G3 | G1, G3 | G2, G3 | G1, G3, G4 | Total (%) | P1A | P1B | P1A, P1B | Total (%) | |
| G3, P1A (47) | 0 | 21 (575) | 4 (200, 1,131) | 1 (800, 800) | 0 | 26 (55) | 34 (289) | 1 (200) | 3 (317, 200) | 38 (81) |
| G1, P1A (23) | 2 (400) | 4 (200) | 6 (252, 504) | 0 | 2 (283, 200, 400) | 14 (61) | 16 (238) | 0 | 1 (200, 200) | 17 (74) |
| Total (70) | 2 (400) | 25 (486) | 10 (230, 696) | 1 (800, 800) | 2 (283, 200, 400) | 40 (57) | 50 (272) | 1 (200) | 4 (282, 200) | 55 (79) |
a
Seroconversion was defined as a fourfold or greater rise in the titer of NtAb in comparisons of the acute- and convalescent-phase sera. The GMTs for the serotypes indicated in the boxheads are shown sequentially in the body of the table. All 70 paired sera were analyzed for the presence of NtAb to G1 and G3 VP7s and NtAb to P1A VP4. For G2 and G4 VP7s and for P1B VP4, we analyzed only the sera in which antibodies to S2 (19 children) or ST3 (17 children) had been previously detected, including sera for which no seroconversion occurred.