Table 1.
Blood pressure (mmHg) and heart rate (bpm) circadian variation for PAG and control animals, before and 59 days after microinjection. Values are expressed as mean ± SEM. Abbreviations: sBP, systolic blood pressure; dBP, diastolic blood pressure; mBP, mean blood pressure; HR, heart rate; PAG, spontaneously hypertensive rats microinjected with LVV-hKir2.1 into the periaqueductal grey matter; and Sham, spontaneously hypertensive rats microinjected with LVV-eGFP into the rostral ventrolateral medulla.*, **, and *** correspond to significant (p < 0.05), very significant (p < 0.009), and extremely significant (p < 0.0005) difference between day 0 and day 60 PAG animals.
| Light Phase | Dark Phase | |||||||
|---|---|---|---|---|---|---|---|---|
| Group | sBP | dBP | mBP | HR | sBP | dBP | mBP | HR |
| Basal conditions | ||||||||
| PAG | 149 ± 2 | 126 ± 3 | 134 ± 3 | 309 ± 6 | 156 ± 3 | 133 ± 5 | 141 ± 4 | 343 ± 8 |
| SHAM | 157 ± 5 | 130 ± 5 | 139 ± 5 | 289 ± 7 | 160 ± 5 | 133 ± 6 | 142 ± 6 | 316 ± 8 |
| 60 days after microinjection | ||||||||
| PAG | 164 ± 2 *** | 140 ± 4 * | 148 ± 3 ** | 284 ± 4 *** | 172 ± 3 ** | 148 ± 7 | 156 ± 5 * | 322 ± 5 ** |
| SHAM | 170 ± 12 | 141 ± 12 | 151 ± 11 | 268 ± 4 | 175 ± 11 | 147 ± 11 | 156 ± 11 | 311 ± 3 |