Table 2.
Blood pressure (mmHg) and heart rate (bpm) circadian variation in KF and control animals before and 59 days after microinjection. Values are expressed as the mean ± SEM. Abbreviations: sBP, systolic blood pressure; dBP, diastolic blood pressure; mBP, mean blood pressure; HR, heart rate; KF, spontaneously hypertensive rats microinjected with LVV-hKir2.1 into the Kolliker-Fuse nucleus; and Sham, spontaneously hypertensive rats microinjected with LVV-eGFP into the rostral ventrolateral medulla. * Statistical significance for comparison between KF days 0 and 60.
| Light Phase | Dark Phase | |||||||
|---|---|---|---|---|---|---|---|---|
| Group | sBP | dBP | mBP | HR | sBP | dBP | mBP | HR |
| Basal conditions | ||||||||
| KF | 148 ± 2 | 127 ± 3 | 134 ± 3 | 322 ± 9 | 152 ± 5 | 131 ± 4 | 138 ± 4 | 353 ± 8 |
| SHAM | 157 ± 5 | 131 ± 6 | 140 ± 5 | 295 ± 5 | 160 ± 5 | 134 ± 6 | 143 ± 6 | 321 ± 6 |
| 60 days after microinjection | ||||||||
| KF | 161 ± 6 * | 138 ± 5 * | 146 ± 5 * | 294 ± 14 * | 166 ± 7 * | 142 ± 6 * | 150 ± 6 * | 327 ± 7 * |
| SHAM | 177 ± 10 | 148 ± 12 | 158 ± 11 | 266 ± 5 | 181 ± 11 | 153 ± 13 | 163 ± 12 | 305 ± 8 |