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Endoplasmic reticulum stress response mechanism [59,60,61,62]. Bip: binding immunoglobulin protein, PERK: PRKR-like endoplasmic reticulum kinase, IRE1a: inositol requiring enzyme 1 alpha, ATF6: activating transcription factor 6, eIF2: eukaryotic translation initiation factor 2, XBP1: X-box binding protein 1, S1p and S2p: site 1 and 2 proteases, CHOP: C/EBP homologous protein.
